Her 3

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v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
Identifiers
Symbol ERBB3
HUGO 3431
Entrez 2065
OMIM 190151
RefSeq NM_001982
UniProt P21860
Other data
Locus Chr. 12 q13

ErbB3 (Her-3) is a member of the EGFR family of receptor tyrosine-kinases. However, despite the namesake of the protein family to which it belongs, ErbB3 does not have kinase activity. Rather, it is thought that ErbB3, when activated, becomes a substrate for dimerization and subsequent phosphorylation by ErbB1, ErbB2 and ErbB4.

Like many of the receptor tyrosine-kinases, ErbB3 is activated by extracellular ligand. Ligands known to bind to ErbB3 include heregulin.

[edit] External links

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Transmembrane receptor, tyrosine kinase: receptor tyrosine kinases

Angiopoietin Receptors: Tie-1 & Tie-2 - Eph - Epidermal growth factor (HER2/neu, Her 3, Her 4) - Fibroblast growth factor (FGFR2) - Flk-1 Flt-1 Insulin - IGF-1 - MuSK - Platelet-derived growth factor - TRK (TrkA, TrkB, TrkC), VEGF Receptors: Flt-1 & KDR/Flk-1,

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Oncogenes/Proto-oncogenes

c-Akt - c-Bcl-2 - c-ErbB (HER2/neu, Her 3) - AP-1 (c-Fos, c-Jun) - c-Mdm2 - c-Met - c-Myc - c-Raf - c-Ras - c-Sis - c-Src

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Tumor markers

Alpha-fetoprotein/AFP-L3 - CA-125 - CD30 - Autocrine motility factor - Carcinoembryonic antigen - erbB-2 receptor - erbB-3 receptor - Neprilysin - Normetanephrine - PCNA - Prostate specific antigen - Synaptophysin

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