Hepoxilin

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Hepoxilin A3
Hepoxilin A3

Hepoxilins are eicosanoid hormones involved in inflammation. They derive from arachidonic acid via oxidation by the enzyme 12-lipoxygenase. Hepoxilins are differentiated from closely related eicosanoids, the leukotrienes and the lipoxins, in that hepoxolins have no conjugated double bonds. In the skin, they are pro-inflammatory , but in neutrophils they are anti-inflammatory.[1] One hepoxilin, HepA3, mediates neutrophil migration across the intestines.[2]

[edit] References

  1. ^ Christie, William W. (2006). LEUKOTRIENES AND LIPOXINS: Chemistry and Biology. Retrieved on January 4, 2007.
  2. ^ Randall J. Mrsny, Andrew T. Gewirtz, Dario Siccardi, Tor Savidge , Bryan P. Hurley , James L. Madara, and Beth A. McCormick (2004). Identification of hepoxilin A3 in inflammatory events: A required role in neutrophil migration across intestinal epithelia. Retrieved on January 4, 2007.
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