Guanosine nucleotide dissociation inhibitors

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The Guanosine nucleotide dissociation inhibitors (GDIs), bind to the GDP-bound form of Rho and Rab small GTPases and not only prevent exchange (maintaining the small GTPase in an off-state), but also prevent the small GTPase from localizing at the membrane, which is their place of action.

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GTP-binding protein regulators

GTPase activating protein: Chimerin 1 - RasGAP - Neurofibromin 1

Guanosine nucleotide dissociation inhibitors

Guanine nucleotide exchange factor: EIF-2 - Son of Sevenless - Ras-GRF1

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