Guanfacine
From Wikipedia, the free encyclopedia
 |
|
|
Guanfacine
|
|
| Systematic (IUPAC) name | |
| N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide | |
| Identifiers | |
| CAS number | |
| ATC code | C02 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C9H9Cl2N3O |
| Mol. mass | 246.093 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
℞ Prescription only |
| Routes | ? |
Guanfacine (brand name Tenex) is a centrally acting antihypertensive agent. Guanfacine lowers both systolic and diastolic blood pressure by activating the central nervous system α-2 adrenergic receptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation.
[edit] Uses
Guanfacine can be used to control high blood pressure. It works by reducing heart rate and relaxing blood vessels.
It is also sometimes prescribed as an off-label treatment for attention-deficit hyperactivity disorder. In August 2006, the makers of Guanfacine applied to the FDA to use this drug to treat ADHD
[edit] Side effects
Usual: Dizziness, drowsiness, headache, constipation, gas pains, diarrhea, loss of appetite, fatigue, and nasal congestion may occur.
Rare: chest pain, shortness of breath, skin rash, swelling of the hands or feet, blurred vision, yellowing of the eyes or skin.
Others: mental/mood changes, tingling of the hands or feet, dry mouth, impotence, decreased sexual desire, vision changes, taste changes, ringing in the ears, leg cramps.
[edit] External links
| Antihypertensives (C02) and diuretics (C03) | |
|---|---|
| Antiadrenergic agents (including alpha) | Clonidine, Doxazosin, Guanethidine, Guanfacine, Lofexidine,Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine |
| Vasodilators | Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine |
| Other antihypertensives | Bosentan, Ketanserin |
| Low ceiling diuretics | Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine, Cicletanine |
| High ceiling diuretics | Bumetanide, Furosemide, Torasemide |
| Potassium-sparing diuretics | Amiloride, Eplerenone, Spironolactone, Triamterene |
 |
This pharmacology-related article is a stub. You can help Wikipedia by expanding it. |
