Griseofulvin

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Griseofulvin
Systematic (IUPAC) name
(2S,6'R)-7-chloro-2',4,6-trimethoxy-6'-methyl-3H, 4'H-spiro[1-benzofuran-2,1'-cyclohex[2]ene]-3,4'-dione
Identifiers
CAS number	126-07-8
ATC code	D01AA08 D01BA01
PubChem	441140
DrugBank	APRD01004
Chemical data
Formula	C17H17ClO6
Mol. mass	352.766 g/mol
Pharmacokinetic data
Bioavailability	Highly variable (25 to 70%)
Metabolism	Hepatic demethylation and glucuronidation
Half life	9-21 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	B3 (Au), C (U.S.)
Legal status	POM (UK), ℞-only (U.S.)
Routes	Oral

Griseofulvin (also known as Grisovin) is an antifungal drug. It is used both in animals and in humans, to treat ringworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum.

It is administered orally.

It binds to keratin in keratin precursor cells and makes them resistant to fungal infections. It is only when hair or skin is replaced by the keratin-griseofulvin complex that the drug reaches its site of action. Griseofulvin will then enter the dermatophyte through energy dependent transport processes and bind to fungal microtubules. This alters the processing for mitosis and also underlying information for deposition of fungal cell walls.

Known side effects:

• Hives
• Skin rashes
• Confusion
• Dizziness
• Diarrhea
• Fatigue
• Headache
• Impairment of performance of routine activities
• Inability to fall or stay asleep
• Nausea
• Oral thrush (yeast infection of the mouth)
• Upper abdominal pain
• Vomiting
• Swelling
• Itching
• Tingling in the hands or feet
• Loss of taste sensation

v • d • e Antifungals (D01 and J02)
Antibiotics	Griseofulvin, Hitachimycin, Natamycin, Nystatin
Topical Azoles	Clotrimazole, Econazole, Fluconazole, Ketoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole
Other topicals	Ciclopirox, Ethylparaben, Flucytosine, Salicylic acid, Selenium sulfide, Terbinafine, Tolnaftate
For systemic use	Amphotericin B, Anidulafungin, Caspofungin, Griseofulvin, Itraconazole, Terbinafine, Voriconazole
Other	Posaconazole, Thiabendazole, Tea tree oil