Grid.org
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- The correct title of this article is grid.org. The initial letter is shown capitalized due to technical restrictions.
grid.org is the website and organization that runs distributed computing projects such as the United Devices Cancer Research Project. It is sponsored by United Devices (UD) and members contribute by running the UD Agent software (version 3.0).
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[edit] Active projects
[edit] Cancer Research Project
The United Devices Cancer Research Project, which began in 2001, is seeking possible drugs for the treatment of cancer using distributed computer power.[1] There are around 150,000 users in the United States and 170,000 in Europe along with hundreds of thousands more in other parts of the world.
The project is an alliance of several companies and organisations:[2]
- United Devices Inc.
- National Foundation for Cancer Research
- University of Oxford Department of Chemistry
- Donors of molecular research
United Devices released the cancer research screensaver under the principle of utilising spare computing power. The program, which can also be set to run continually, uses "virtual screening" to find possible interactions between molecules and target proteins, i.e. a drug. These molecules (ligands) are sent to the host computer's UD Agent. When these molecules dock successfully with a target protein this interaction is scored for further investigation.
Phase 1 has been completed and Phase 2 is underway. In Phase 1, over 3 billion drug-like molecules were tested against 12 proteins which are known as suitable targets for anti-cancer drugs. It used the "THINK" software for the simulation of the molecular interactions.[3]
Phase 2, using the "LigandFit" software developed by Accelrys to model interactions, seeks to refine the Phase 1 data to produce a more manageable list of drug candidates for testing that will require experimental collaborators, including some from industry.[4][5]
[edit] Completed projects
[edit] Human Proteome Folding Project, phase 1
The IBM-sponsored Human Proteome Folding Project ("HPF"), phase 1, was announced on November 16, 2004 and was completed July 3, 2006. The project operated simultaneously on both grid.org and the IBM's World Community Grid.[6]
It made use of the "Rosetta" software to predict the structure of human proteins in order to help predict the function of proteins. This information may someday be used to help cure a variety of diseases and genetic defects.
According to an announcement on the grid.org forums,[7] after the HPF1 project was completed it was left to continue running on grid.org until August 9, 2006.[8] During that time, members whose computers were configured to run this project got new work and spent computing resources calculating a result, but the result was returned to grid.org for points only -- it was not used for scientific research.
The status of the Human Proteome Folding Project caused some discussion on the grid.org forums. Most members wanted to see all available computing power directed toward the still-active Cancer project,[8] but UD representative Robby Brewer asserted that "some [users] like the screensaver".[7][9] As noted above, in the end the redundant HPF1 work on grid.org was halted.[8]
[edit] Smallpox Project
The Smallpox Research Grid was a part of United Devices "Patriot Grid" initiative to fight biological terrorism. This project helped analyze potential drug candidates for a medical therapy in the fight against smallpox virus. It made use of the "LigandFit" software (that had already been used by phase 2 of the Cancer Research project), but with a specialized set of target molecules that targeted the smallpox virus.[10] 35 million potential drug molecules were screened against several smallpox proteins, resulting in 44 strong potential treatments.[citation needed]
The partners of the project included University of Oxford, the University of Western Ontario, Memorial Sloan Kettering Cancer Research Center, Essex University, Evotec OAI, Accelrys, and IBM.[11]
The World Community Grid largely began because of the success of this project in shaving years off research time.
[edit] Anthrax Project
The Anthrax Research Project was a part of the United Devices "Patriot Grid" initiative to fight biological terrorism. It made use of the "LigandFit" software (that had already been used by phase 2 of the Cancer Research project), but with a specialized set of target molecules that targeted the advanced stages of anthrax bacterial infection.
The project was operated from January 22, 2002 until February 14, 2002 and ended after a total of 3.57 billion molecules had finished screening. The results of the research project were transmitted to biological scientists in order to finish the screening of the computational simulations.[12]
The partners of the project included Oxford University.
[edit] Inactive/past projects
[edit] HMMER Project
The HMMER Genetic Research project made use of the Hidden Markov model to search for patterns in genetic DNA sequences.[13]
[edit] Webload Project
The Web Performance Testing project was operated as a commercial opportunity with select web hosting providers in order to help them test the scalability of their server infrastructures under periods of high-demand.[14]
[edit] See also
[edit] References
- ^ "Screensaver aids cancer fight", BBC News, 2001-04-03. Retrieved on 2006-08-20.
- ^ Cancer Project Participants. grid.org. Retrieved on 2006-08-20.
- ^ Think phase 1 computation. University of Oxford. Retrieved on 2006-08-20.
- ^ LigandFit explained. grid.org. Retrieved on 2006-08-20.
- ^ Phase 2 of the Project. University of Oxford. Retrieved on 2006-08-20.
- ^ About The Human Proteome Folding Project. grid.org (2004). Retrieved on 2006-08-20.
- ^ a b Brewer, Robby (2006-07-10). Grid.org Status. grid.org forums. Retrieved on 2006-08-20.
- ^ a b c Take responsibility. grid.org forums (2006-07-17). Retrieved on 2006-08-20.
- ^ Brewer, Robby (2006-08-21). Grid.org status. grid.org forums. Retrieved on 2006-08-20.
- ^ About The Smallpox Project. grid.org. Retrieved on 2006-08-20.
- ^ Smallpox participants. grid.org. Retrieved on 2006-08-20.
- ^ The Anthrax Research Project. grid.org. Retrieved on 2006-08-20.
- ^ Genetic Testing with HMMR. grid.org. Retrieved on 2006-08-20.
- ^ Web Performance Testing. grid.org. Retrieved on 2006-08-20.
