Grapefruit juice
From Wikipedia, the free encyclopedia
Grapefruit juice is the fruit juice coming from grapefruits. It is rich with Vitamin C and is quite sour. Variations include pink grapefruit juice.[1][2]
[edit] Drug interactions
Grapefruit juice, and grapefruit in general, is a potent inhibitor of the Cytochrome_P450 enzyme CYP3A4, which can impact the metabolism of a variety of drugs, increasing their bioavailability.[3][4][5][6][7] In some cases, this can lead to a fatal interaction with drugs like Astemizole.[4] The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. However, the effect became well-publicized after being responsible for a number of deaths due to overdosing on medication.[8]
[edit] See also
[edit] References
- ^ The World's Healthiest Foods; Grapefruit. The George Mateljan Foundation. Article
- ^ Fellers PJ, Nikdel S, Lee HS. Nutrient content and nutrition labeling of several processed Florida citrus juice products. J Am Diet Assoc. 1990 Aug;90(8):1079-84. Abstract
- ^ He K; Iyer KR; Hayes RN; Sinz MW; Woolf TF; Hollenberg PF. Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. Chem Res Toxicol. 1998 Apr;11(4):252-9. Abstract
- ^ a b Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol. 1998 Aug;46(2):101-10. Comment in: Br J Clin Pharmacol. 2001 Aug;52(2):216-7. Abstract
- ^ Garg SK, Kumar N, Bhargava VK, Prabhakar SK. Effect of grapefruit juice on carbamazepine bioavailability in patients with epilepsy. Clin Pharmacol Ther. 1998 Sep;64(3):286-8. Abstract
- ^ Bailey DG, Dresser GK. Interactions between grapefruit juice and cardiovascular drugs. Am J Cardiovasc Drugs. 2004;4(5):281-97. Abstract
- ^ Bressler R. Grapefruit juice and drug interactions. Exploring mechanisms of this interaction and potential toxicity for certain drugs. Geriatrics. 2006 Nov;61(11):12-8. Abstract
- ^ Bakalar, Nicholas. Experts Reveal the Secret Powers of Grapefruit Juice. New York Times. Published: March 21, 2006. Article
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