Talk:Glycosylation
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OGalNAc: When you say proteins in the blood do not normally contain O-linked glycans and you give three examples that do, are you refering to OGalNAc specifically? Thrombospondins contain O-fucose, and many many proteins are predicted to have both O-fucose and O-glucose so this statement is probably too strong and should be changed to refer specifically to OGalNAc if that is the case or be removed altogether.
glucosepane
Recent research suggests that glucosepane is an important crosslink in aging. In Cross-linking of the extracellular matrix by the maillard reaction in aging and diabetes: an update on "a puzzle nearing resolution", Monnier VM, Mustata GT, Biemel KL, Reihl O, Lederer MO, Zhenyu D, Sell DR. write: " we provide an update of the field that leads to the conclusion that, while oxidation might be important for Maillard reaction-mediated cross-linking via Strecker degradation and allysine formation, the single most important collagen cross-link known to date in diabetes and aging is glucosepane, a lysyl-arginine cross-link that forms under nonoxidative conditions." PMID: 16037276
I am not sure where this information should be added.
It would also be good if someone more knowledgable than me could add an entry for glucosepane.
Not on this page see glycation for non-enzymatic reactions involving the addition of monosaccharides Ianmc 21:50, 30 April 2006 (UTC)
Ok. Copied above to the glycation discussion. --Manfred Bartz 10:42, 4 May 2006 (UTC)
