Glucuronidation
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Glucuronidation is the process of chemically binding a substance to glucuronic acid via a glycosidic bond. The resulting glucuronide is typically much more water soluble than the original substance. The human body uses glucuronidation to excrete a large variety of molecules, including drugs, pollutants, bilirubin, androgens, estrogens, mineralocorticoids, glucocorticoids, fatty acid derivatives, retinoids and bile acids.[1] Most of this is done by liver UDP-glucuronosyltransferases.[2]
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[edit] Acyl glucuronidation
Acyl glucuronidation is an important metabolic pathway for fluoroquinolone antibiotics.
[edit] N-glucuronidation
[edit] External links
- Species Differences in N-Glucuronidation
- N-glucuronidation of nicotine and cotinine by human liver microsomes...
- N-glucuronidation of trans-3'-hydroxycotinine by human liver microsomes
- Ethnic differences in N-glucuronidation of nicotine and cotinine
[edit] References
- ^ King C, Rios G, Green M, Tephly T (2000). "UDP-glucuronosyltransferases". Curr Drug Metab 1 (2): 143-61. PMID 11465080.
- ^ Bock K, Köhle C. "UDP-glucuronosyltransferase 1A6: structural, functional, and regulatory aspects". Methods Enzymol 400: 57-75. PMID 16399343.
- Mannfred A Hollinger, Introduction to Pharmacology, ISBN 0-415-28033-8
- Chang, K. M.; McManus, K.; Greene, J.; Byrd, G. D.; DeBethizy, J. D. Glucuronidation as a metabolic pathway for nicotine metabolism. 1991
- Coffman B.L., King C.D., Rios G.R. and Tephly T.R. The glucuronidation of opioids, other xenobiotics, and androgens by human
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