Glucose isomerase

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Glucose phosphate isomerase

Enzyme Phosphoglucose isomerase
PDB Code PDB 1GZV
Organism Pig
Tissue Muscle
Complexed molecules 5-phosphoarabinoate
Symbol(s): GPI
Genetic data
Locus: Chr. 19 q13.1
Database Links
EC number: 5.3.1.9
Entrez: 2821
OMIM: 172400
RefSeq: NM_000175
UniProt: P06744

Glucose isomerase is an enzyme (EC 5.3.1.9) that catalyzes the conversion of glucose into fructose. In the glycolysis pathway phosphoglucose isomerase converts glucose-6-phosphate to fructose-6-phosphate. These reactions are reversible.

[edit] In glycolysis

α-D-Glucose 6-phosphate Phosphoglucose isomerase β-D-Fructose 6-phosphate
image:Glucose-6-phosphate_wpmp.png   image:Fructose-6-phosphate_wpmp.png
 
  Phosphoglucose isomerase

Compound C00668 at KEGG Pathway Database. Enzyme 5.3.1.9 at KEGG Pathway Database. Compound C05345 at KEGG Pathway Database. Reaction R00771 at KEGG Pathway Database.

[edit] As a glucose isomerase

D-Glucose Phosphoglucose isomerase D-Fructose
image:D-glucose_wpmp.png   Image:D-fructose wpmp.png
 
  Phosphoglucose isomerase

[edit] Other functions

There is evidence that phosphoglucose isomerase acts as a molecular messenger. It is produced and secreted by white blood cells, and acts to regulate the growth of several different cell types.



 v • d • e 
Glycolysis Metabolic Pathway
Glucose Glucose-6-phosphate Fructose 6-phosphate Fructose 1,6-bisphosphate Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Glyceraldehyde 3-phosphate
ATP ADP ATP ADP NAD+ + Pi NADH + H+
+ 2
NAD+ + Pi NADH + H+
1,3-Bisphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate Phosphoenolpyruvate Pyruvate Acetyl-CoA
ADP ATP H2O ADP ATP CoA + NAD+ NADH + H+ + CO2
2 2 2 2 2 2
ADP ATP H2O
v • d • e
Carbohydrate metabolism: gluconeogenesis enzymes

Pyruvate carboxylase

Phosphoenolpyruvate carboxykinase - Fructose bisphosphatase - Glucose isomerase

v • d • e
Carbohydrate metabolism: glycolysis enzymes

Hexokinase - Glucose isomerase - Phosphofructokinase - Aldolase - Triosephosphate isomerase - Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase

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