Glomerular basement membrane

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Glomerular basement membrane
Glomerulus. (Diagram in French, but "Membrane basale glomerulaire et ses podocytes" labeled near center.)
MeSH	glomerular+basement+membrane
Dorlands/Elsevier	m_08/12522684

The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration though the filtration slits between the podocytes , separating the blood on the inside from the urine on the outside.^[1]

Contents 1 Layers 2 Pathology 3 See also 4 References 5 External links

[edit] Layers

The GBM contains three layers: ^[2]

lamina rara externa	by heparan sulfate	blocks by charge
lamina densa	by type 4 collagen	blocks by size
lamina rara interna	heparan sulfate	blocks by charge

[edit] Pathology

• Goodpasture's syndrome is also known as "anti-glomerular basement membrane disease".

[edit] See also

• basement membrane
• nephrin

[edit] References

1. ^ Physiology at MCG 7/7ch04/7ch04p07 - "Basement Membrane"
2. ^ http://www.jci.org/cgi/content/full/116/8/2090/F1

[edit] External links

• MeSH glomerular+basement+membrane
• "The GBM and its disorders" at dmed.ed.ac.uk
• Histology at harvard.edu
• Structure at wramc.army.mi

v • d • e Urinary system - Kidney

Renal fascia, Renal capsule, Renal cortex  (Renal column), Renal medulla (Renal sinus, Renal pyramids), Renal lobe, Cortical lobule, Medullary ray, Nephron afferent circulation: Renal artery → Interlobar arteries → Arcuate arteries → Cortical radial arteries → Afferent arterioles → Renal corpuscle (Glomerulus, Bowman's capsule) kidney tubule: Proximal tubule → Loop of Henle (Descending, Thin ascending, Thick ascending)  → Distal convoluted tubule → Connecting tubule → Collecting ducts → Duct of Bellini → Renal papilla → Minor calyx → Major calyx → Renal pelvis → Ureter efferent circulation: Glomerulus → Efferent arterioles → Peritubular capillaries/Vasa recta → Arcuate vein→ Interlobar veins→ Renal vein juxtaglomerular apparatus: Macula densa, Juxtaglomerular cells, Extraglomerular mesangial cells filtration: Glomerular basement membrane - Podocyte - Filtration slits - Intraglomerular mesangial cells