Gliclazide

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Gliclazide
Systematic (IUPAC) name
3-(7-azabicyclo[3.3.0]oct-7-yl)- 1-(4-methylphenyl)sulfonyl-urea
Identifiers
CAS number	21187-98-4
ATC code	A10BB09
PubChem	3475
DrugBank	APRD00460
Chemical data
Formula	C15H21N3O3S
Mol. mass	323.412 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Gliclazide is an oral hypoglycemic (anti-diabetic drug) and is classified as a sulfonylurea. It is marketed as Diamicron MR®. DIAMICRON MR is also distributed as: Diabeton MR, Diamicron 30mg, Diamicron LM 30mg, Diamicron MR 30 mg, Diamicron Uno 30mg, Dianormax MR, Diaprel MR and Uni Diamicron.

• Official site

Contents 1 Form and Composition: 2 Indication: 3 Dosage: 4 Properties: 5 Contraindications: 6 Interactions: 7 Adverse effects: 8 Overdosage:

[edit] Form and Composition:

Each modified-release tablet contains 30 mg of gliclazide.

[edit] Indication:

Type 2 diabetes.

[edit] Dosage:

30 to 120 mg depending on response, once daily with breakfast, including in elderly patients or those with mild-to-moderate renal failure

[edit] Properties:

Hypoglycemic sulfonylurea, restoring first peak of insulin secretion, increasing insulin sensitivity. Glycemia-independent hemovascular effects, antioxidant effect. No active circulating metabolites.

[edit] Contraindications:

type 1 diabetes, hypersensitivity to sulfonylureas, severe renal or hepatic failure, pregnancy and lactation, miconazole coprescription.

[edit] Interactions:

Hyperglycemic action may be caused by danazol, chlorpromazine, glucocorticoids, progestogens, ß-2 agonists. Its hypoglycemic action may be potentiated by phenylbutazone, alcohol, fluconazole, ß-blockers, possibly ACE inhibitors.

[edit] Adverse effects:

Hypoglycemia, gastrointestinal disturbance (reported), skin reactions (rare), hematological disorders (rare), hepatic enzyme rises (exceptional).

[edit] Overdosage:

Possible severe hypoglycemia requiring urgent IV glucose and monitoring.

v • d • e Oral antidiabetic drugs (A10B)
Biguanides	Metformin
Sulfonylureas	Chlorpropamide, glibenclamide (Glyburide), Gliclazide, Glimepiride, Glipizide, Gliquidone, Tolazamide, Tolbutamide
Alpha-glucosidase inhibitors	Acarbose, Miglitol
Thiazolidinediones (TZD)	Pioglitazone, Rosiglitazone, Troglitazone
Meglitinides	Nateglinide, Repaglinide, Mitiglinide
Dipeptidyl peptidase-4 (DPP-4) inhibitors	Saxagliptin, Sitagliptin, Vildagliptin