GDF1
From Wikipedia, the free encyclopedia
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growth differentiation factor 1
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| Identifiers | |
| Symbol | GDF1 |
| HUGO | 4214 |
| Entrez | 2657 |
| OMIM | 602880 |
| RefSeq | NM_001492 |
| UniProt | P27539 |
| Other data | |
| Locus | Chr. 19 p12 |
Growth differentiation factor-1 (GDF1) is a protein belonging to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.[1] It is found in the brain, spinal cord and peripheral nerves of embryos[2][3]
[edit] References
- ^ Rankin C, Bunton T, Lawler A, Lee S (2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat Genet 24 (3): 262-5. PMID 10700179.
- ^ Lee S (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc Natl Acad Sci U S A 88 (10): 4250-4. PMID 2034669.
- ^ Rankin C, Bunton T, Lawler A, Lee S (2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat Genet 24 (3): 262-5. PMID 10700179.
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TGF beta superfamily of ligands:
Activin A and B - Anti-müllerian hormone - Bone morphogenetic proteins (BMP2, BMP3, BMP4, BMP5, BMP6, BMP7, BMP8a, BMP8b, BMP10 , BMP15) - Growth differentiation factors (GDF1, GDF2, GDF3, GDF5, GDF6, GDF7, GDF9, GDF10, GDF11, GDF15) - Inhibin A and B - Myostatin - Nodal - TGF beta family (TGF-β1, TGF-β2, TGF-β3)
Type II receptors:ACVR2A - ACVR2B - AMHR2 - BMPR2 - TGFBR2 - TGFBR3
Type I receptors: ACVR1A - ACVR1B - ACVR1C - ACVRL1 - BMPR1A - BMPR1B - TGFBR1
Signal transducers/SMAD: R-SMAD (SMAD1, SMAD2, SMAD3, SMAD5, SMAD9) - I-SMAD (SMAD6, SMAD7) - SMAD4
Ligand Inhibitors: Cerberus - Chordin - DAN - Decorin - Follistatin - Gremlin - Lefty - LTBP1 - Noggin - THBS1
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