GDF15

From Wikipedia, the free encyclopedia

growth differentiation factor 15
Identifiers
Symbol	GDF15 PLAB, MIC-1, PDF, MIC1, NAG-1, PTGFB
HUGO	30142
Entrez	9518
OMIM	605312
RefSeq	NM_004864
UniProt	Q99988
Other data
Locus	Chr. 19 p13.1-13.2

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.^[1] GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.^[2] GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as liver, kidney, heart and lung.^[1][2][3]

[edit] References

1. ^ ^{a b} Zimmers T, Jin X, Hsiao E, McGrath S, Esquela A, Koniaris L (2005). "Growth differentiation factor-15/macrophage inhibitory cytokine-1 induction after kidney and lung injury". Shock 23 (6): 543-8. PMID 15897808. 
2. ^ ^{a b} Hsiao E, Koniaris L, Zimmers-Koniaris T, Sebald S, Huynh T, Lee S (2000). "Characterization of growth-differentiation factor 15, a transforming growth factor beta superfamily member induced following liver injury". Mol Cell Biol 20 (10): 3742-51. PMID 10779363. 
3. ^ Ago T, Sadoshima J (2006). "GDF15, a cardioprotective TGF-beta superfamily protein". Circ Res 98 (3): 294-7. PMID 16484622.