Gadodiamide

From Wikipedia, the free encyclopedia

Gadodiamide
Systematic (IUPAC) name
2-[bis[2-(carboxylatomethyl-(methylcarbamoylmethyl)amino)ethyl]amino]acetate; gadolinium(+3) cation
Identifiers
CAS number	122795-43-1
ATC code	?
PubChem	60754
Chemical data
Formula	C16H28GdN5O9
Mol. mass	591.672g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	negligible
Metabolism	not metabolized
Half life	77.8 minutes
Excretion	renal
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	i.v.

Gadodiamide is a gadolinium based contrast agent used in MR imaging procedures to assist in the visualization of blood vessels. It is commonly marketed under the trade name Omniscan.

[edit] Uses

Gadodiamide is used to visualize blood vessels during MRI procedures. The use of gadodiamide in these scans allows for the diagnosis of intracranial lesions or blood-brain barrier anomolies.^[1] It is a high osmolarity contrast agent at 789 mOsmol per kg of water.

Gadolinium based agents may cause a toxic reaction known as NSF in patients with kidney problems.

[edit] References

1. ^ Gadodiamide Drug Information. Drugs.com Professional. Micromedex (9 January 2007). Retrieved on February 19, 2007.