Friedländer synthesis

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The Friedländer synthesis is the chemical reaction of 2-aminobenzaldehydes[1] with ketones to form quinoline derivatives.[2][3] It is named after German chemist Paul Friedländer (1857-1923).

The Friedländer synthesis

Several reviews have been published.[4][5][6]

[edit] References

  1. ^  Organic Syntheses, Coll. Vol. 3, p.56 (1955); Vol. 28, p.11 (1948). (Article)
  2. ^  Friedländer, P. Ber. 1882, 15, 2572.
  3. ^  Friedländer, P.; Gohring, C. F. Ber. 1883, 16, 1833.
  4. ^  Manske, R. H. Chem. Rev. 1942, 30, 113. (Review)
  5. ^  Bergstrom, F. W. Chem. Rev. 1944, 35, 77. (Review)
  6. ^  Cheng, C. C.; Yan, S. J. Org. React. 1982, 28, 37. (Review)

[edit] See also


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