Fragment crystallizable region

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An antibody digested by papain yields two fragments, two Fab fragments and one Fc fragment
An antibody digested by papain yields two fragments, two Fab fragments and one Fc fragment
Schematic diagram showing Fc receptor interaction with an antibody-coated microbial pathogen
Schematic diagram showing Fc receptor interaction with an antibody-coated microbial pathogen

The fragment crystallizable region (Fc region) is a region of an antibody composed of two heavy chains that each contribute two to three constant domains, depending on the class of the antibody.[1]

[edit] Function

Fc binds to various cell receptors and complement proteins.

In this way, it mediates different physiological effects of antibodies (opsonization, cell lysis, degranulation of mast cells, basophils and eosinophils and other processes).

[edit] See also

[edit] References

  1. ^ Janeway CA, Jr. et al (2001). Immunobiology., 5th ed., Garland Publishing. (electronic full text via NCBI Bookshelf) ISBN 0-8153-3642-X. 
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