Talk:FOXP2
From Wikipedia, the free encyclopedia
 |
This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The current monthly improvement drive is Signal transduction. | ||
|
Article Grading: The article has not been rated for quality and/or importance yet. Please rate the article and then leave comments here to explain the ratings and/or to identify the strengths and weaknesses of the article.. |
|||
The link to www.timesonline.co.uk appears to be broken.
D. F. Newbury, E. Bonora, J. A. Lamb, S. E. Fisher, C. S. L. Lai, G. Baird, L. Jannoun, V. Slonims, C. M. Stott, M. J. Merricks, P. F. Bolton, A. J. Bailey, A. P. Monaco (2002) "FOXP2 Is Not a Major Susceptibility Gene for Autism or Specific Language Impairment" in American Journal of Human Genetics.
- In the absence of any mutation or association evidence to suggest otherwise, we must therefore conclude that FOXP2 is unlikely to play a major role in the onset of autism or SLI.
I think FOXP2 is the name of a particular a locus not a gene. To call it a gene is misleading. —The preceding unsigned comment was added by 82.41.31.3 (talk • contribs) 23:01, 5 May 2006.
From the NCBI Genbank database, "This gene encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified." Braingrind 00:14, 6 May 2006 (UTC)
