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by substituting a 9alpha fluoro grp onto an analog of 17alpha methyltestosterone, fluoxymesterone has 20x the anabolic and 10x the androgenic activity. it has a mean halflife of 9hrs and < 5% of the drug is excreted unchanged. adverse effects include sodium and water retention that can cause edema.
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Fluoxymesterone
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| Systematic (IUPAC) name |
| 9-fluoro-11,17- dihydroxy-10,13,17- trimethyl-1,2,6,7,8,11,12,14,15,16- decahydrocyclopenta[a] phenanthren-3-one |
| Identifiers |
| CAS number |
76-43-7 |
| ATC code |
G03BA01 |
| PubChem |
6446 |
| DrugBank |
APRD00981 |
| Chemical data |
| Formula |
C20H29FO3 |
| Mol. mass |
336.441 g/mol |
| Pharmacokinetic data |
| Bioavailability |
? |
| Metabolism |
? |
| Half life |
9.2 hours |
| Excretion |
? |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
|
| Routes |
? |
Fluoxymesterone is an androgen hormone.
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Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS |
Progestogens:
(receptor) |
PROGESTERONE, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin, Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone
Antiprogestogen: Mifepristone |
Androgens:
(receptor) |
TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids)
Antiandrogens: Bicalutamide, Cyproterone, Flutamide, Nilutamide, Spironolactone |
Estrogens:
(receptor) |
ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate
Selective estrogen receptor modulator: Bazedoxifene, Clomifene, Fulvestrant, Raloxifene, Tamoxifen, Toremifene
Aromatase inhibitor: Aminogluthetimide, Anastrozole, Exemestane, Formestane, Letrozole, Vorozole |
Gonadotropins:
(FSHR/LHCGR) |
ovulation stim.:Clomifene, Urofollitropin
Antigonadotropins: Danazol, Gestrinone |
GnRH:
(receptor) |
agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin
antagonist: Abarelix, Cetrorelix, Ganirelix |
