Fecal bacteriotherapy

From Wikipedia, the free encyclopedia

Fecal bacteriotherapy, also known as fecal transfusion or fecal transplant, is a medical treatment in which bacteria from feces of a healthy person are transferred into the large bowel and rectum of a patient. It is an alternative treatment for patients with pseudomembranous colitis (caused by Clostridium difficile), Ulcerative colitis and Crohn's disease.

Contents 1 Description of procedure 2 Theoretical basis 3 Effectiveness 4 History 5 See also 6 External links 7 References

[edit] Description of procedure

The procedure itself involves a 5 to 10 day treatment with enemas, made of bacterial flora from feces of a healthy donor (who needs to be tested for a wide array of bacterial and parasitic agents). The enemas are prepared and administered in a hospital environment to ensure all necessary precautions. Regular checkups are required up to a year following the procedure.

[edit] Theoretical basis

The hypothesis behind fecal bacteriotherapy is that inflammatory bowel disease may, like in the case of pseudomembranous colitis, be a previous infection by a still unidentified pathogen which somehow damages the healthy bacterial flora of the colon, causing a bacterial imbalance, which then proceeds to reinfect and damage the colon in an endless cycle which can be broken by "recolonizing" the colon with bacteria from a healthy bowel^[1]. This may be considered an extension of probiotic research.

[edit] Effectiveness

The procedure has been used to successfully cure C. difficile infections for a number of years, with a success rate of nearly 95% according to some sources^[2][3][4].

While its effects on ulcerative colitis and Crohn's disease have not yet been adequately researched, small case series suggest it has positive effects. A recent article by Dr. Borody in which he details 6 cases of severe chronic ulcerative colitis treated using Fecal bacteriotherapy suggests that the procedure may be extremely successful in these cases as well. Complete reversal of symptoms was achieved in all patients by 4 months post-HPI, by which time all other UC medications had been ceased. At 1 to 13 years post-HPI and without any UC medication, there was no clinical, colonoscopic, or histologic evidence of UC in any patient^[5]. The Sydney group also reports a case of presumed sclerosing cholangitis, a disease frequently associated with IBD, which recovered fully after the treatment.

[edit] History

It has been developed in recent years by Dr. Thomas J. Borody and his team in Sydney, Australia, primarily as an alternative treatment for pseudomembranous colitis. This disease is caused by C. difficile infection, and is typically treated with antibiotics.

[edit] See also

• Pseudomembranous colitis
• Ulcerative colitis
• Crohn's disease
• Inflammatory bowel disease
• Helminthic therapy

[edit] External links

• Center for Digestive Diseases, Sydney, Australia
• Probiotic Therapy Research Centre, Sydney, Australia

[edit] References

v • d • e Health science - Medicine - Gastroenterology (primarily K)
esophagus - stomach:	Halitosis | Nausea | Vomiting | Heartburn | GERD | Achalasia | Esophageal cancer | Esophageal varices | Peptic ulcer | Abdominal pain | Stomach cancer | Non-ulcer dyspepsia | Gastroparesis
liver - pancreas - gallbladder - biliary tree:	Hepatitis | Cirrhosis | NASH | PBC | PSC | Budd-Chiari | Hepatocellular carcinoma | Acute pancreatitis | Chronic pancreatitis | Hereditary pancreatitis
small intestine:	Peptic ulcer | Intussusception | Malabsorption (e.g. coeliac, lactose intolerance, fructose malabsorption, Whipple's)
colon:	Diarrhea | Appendicitis | Diverticulitis | Diverticulosis | IBD (Crohn's, Ulcerative colitis)