Farnesoid X receptor
From Wikipedia, the free encyclopedia
|
nuclear receptor subfamily 1, group H, member 4
|
|
| Identifiers | |
| Symbol | NR1H4 |
| HUGO | 7967 |
| Entrez | 9971 |
| OMIM | 603826 |
| RefSeq | NM_005123 |
| UniProt | Q96RI1 |
| Other data | |
| Locus | Chr. 12 q22-12q24.1 |
The farnesoid X receptor (FXR) is a nuclear hormone receptor with activity similar to that seen in other steroid receptors such as estrogen or progesterone but more similar in form to PPAR, LXR and RXR.
Chenodeoxycholic acid and other bile acids are the natural ligand for FXR and like other steroid receptors, when activated, it translocates to the cell nucleus, forms a dimer (in this case a heterodimer) and binds to hormone response elements on DNA which elicits expression or transrepression of gene products. One of the primary functions of FXR activation is the suppression of cholesterol 7 alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis from cholesterol.
[edit] External links
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
CAP - CBF - E2F - KlF - Nanog - NF-kB - Oct-4 - P300/CBP - PIT-1 - Rho/Sigma - R-SMAD - Sox2 - Sp1 - STAT (STAT1, STAT3, STAT5)
Basic-helix-loop-helix: AhR - HIF - MYC - Twist - Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6)
Basic leucine zipper: C/EBP - CREB - AP-1
Basic helix-loop-helix leucine zipper: MITF - SREBP
Nuclear receptors: subfamily 1 (Thyroid hormone, RAR, PPAR, LXR, FXR, Calcitriol, PXR, CAR) - subfamily 2 (HNF4, RXR) - subfamily 3/Steroid hormone (Estrogen, Estrogen related, Glucocorticoid, Mineralocorticoid, Progesterone, Androgen) - subfamily 0 (NR0B1)
