Estrogen related receptor
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estrogen-related receptor alpha
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| Identifiers | |
| Symbol | ESRRA ESRL1 |
| HUGO | 3471 |
| Entrez | 2101 |
| OMIM | 601998 |
| RefSeq | NM_004451 |
| UniProt | P11474 |
| Other data | |
| Locus | Chr. 11 q12 |
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estrogen-related receptor beta
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| Identifiers | |
| Symbol | ESRRB ESRL2 |
| HUGO | 3473 |
| Entrez | 2103 |
| OMIM | 602167 |
| RefSeq | NM_004452 |
| UniProt | O95718 |
| Other data | |
| Locus | Chr. 14 q24.3 |
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estrogen-related receptor gamma
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| Identifiers | |
| Symbol | ESRRG |
| HUGO | 3474 |
| Entrez | 2104 |
| OMIM | 602969 |
| RefSeq | NM_206595 |
| UniProt | P62508 |
| Other data | |
| Locus | Chr. 1 q41 |
There are three known estrogen related receptors:
- ERRalpha
- ERRbeta
- ERRgamma
The ERRs are members of the orphan nuclear receptor family.
ERR's bind to estrogen response elements on DNA and modulate transcription but do not bind to endogenous estrogens.
In addition, ERR's seem to have their own response elements termed ERRE's. ERR's have been shown to play a role in energy homeostasis and cancer.[1]
[edit] References
- ^ Ariazi E, Jordan V (2006). "Estrogen-related receptors as emerging targets in cancer and metabolic disorders". Curr Top Med Chem 6 (3): 203-15. PMID 16515477.
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This biochemistry article is a stub. You can help Wikipedia by expanding it. |
CAP - CBF - E2F - KlF - Nanog - NF-kB - Oct-4 - P300/CBP - PIT-1 - Rho/Sigma - R-SMAD - Sox2 - Sp1 - STAT (STAT1, STAT3, STAT5)
Basic-helix-loop-helix: AhR - HIF - MYC - Twist - Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6)
Basic leucine zipper: C/EBP - CREB - AP-1
Basic helix-loop-helix leucine zipper: MITF - SREBP
Nuclear receptors: subfamily 1 (Thyroid hormone, RAR, PPAR, LXR, FXR, Calcitriol, PXR, CAR) - subfamily 2 (HNF4, RXR) - subfamily 3/Steroid hormone (Estrogen, Estrogen related, Glucocorticoid, Mineralocorticoid, Progesterone, Androgen) - subfamily 0 (NR0B1)
