ERCC2 gene
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excision repair cross-complementing rodent repair deficiency, complementation group 2 (xeroderma pigmentosum D)
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| Identifiers | |
| Symbol | ERCC2 XPD |
| HUGO | 3434 |
| Entrez | 2068 |
| OMIM | 126340 |
| RefSeq | NM_000400 |
| UniProt | P18074 |
| Other data | |
| Locus | Chr. 19 q13.3 |
ERCC2, or XPD can be regarded as a nucleotide excision repair protein.
The XPD (ERCC2) gene encodes for a 2.3-kb mRNA containing 22 exons and 21 introns. The XPD protein is a 760 amino acids polypeptide with a size of 87kDa.
Just like XPB, XPD is also a part of human transcriptional initiation factor TFIIH and has ATP-dependent helicase activity.
XPD is essential for the viability of cells. Deletion of XPD in mice is embryonic lethal.
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