Echothiophate

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Echothiophate
Systematic (IUPAC) name
2-diethoxyphosphorylsulfanylethyl-trimethyl-ammonium iodide
Identifiers
CAS number	6736-03-4
ATC code	S01EB03
PubChem	10547
DrugBank	APRD00942
Chemical data
Formula	C9H23INO3PS
Mol. mass	383.228 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	?

Echothiophate is a parasympathomimetic and organophosphate which binds irreversibly to cholinesterase. Because of the very slow rate at which echothiophate is hydrolyzed by cholinesterase, its effects can last a week or more.

Contents 1 Clinical uses 2 Shortage 3 Sources 4 External links

[edit] Clinical uses

Echothiophate is used as ocular drops in the treatment of chronic glaucoma. It is available under several trade names such as Phospholine Iodide (Wyeth-Ayerst).

[edit] Shortage

Wyeth Pharmaceuticals stopped manufacturing echothiophate iodide (phospholine iodide) in the US in 2003. After contacting the American Academy of Ophthalmology (AAO), Wyeth rescinded their decision and, according to AAO public relations representative Michelle Stephens, the AAO and Wyeth were in talks for about a year about manufacturing it.

In the meantime, a worldwide shortage of the drug has occurred.

[edit] Sources

• Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
• Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

[edit] External links

• Eurotimes article: "Echothiophate iodide shortage leaves US specialists struggling to find alternative for acute cases"

• Links to external chemical sources

v • d • e Antiglaucoma preparations and miotics (S01E)
Sympathomimetics	Apraclonidine, Brimonidine, Clonidine, Dipivefrine, Epinephrine
Parasympathomimetics	Aceclidine, Acetylcholine, Carbachol, Demecarium, Echothiophate, Fluostigmine, Neostigmine, Paraoxon, Physostigmine, Pilocarpine
Carbonic anhydrase inhibitors	Acetazolamide, Brinzolamide, Diclofenamide, Dorzolamide, Methazolamide
Beta blocking agents	Befunolol, Betaxolol, Carteolol, Levobunolol, Metipranolol, Timolol
Prostaglandin analogues	Bimatoprost, Latanoprost, Travoprost, Unoprostone
Other agents	Dapiprazole, Guanethidine