Donovan's Brain
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Donovan's Brain is a 1942 horror novel by Curt Siodmak.
Spoiler warning: Plot and/or ending details follow.
The story revolves around an attempt to keep alive the brain of millionaire megalomaniac W.H. Donovan after an otherwise fatal plane crash. Gradually, the increasingly evil brain develops telepathic abilities and becomes able to control the mind of Dr. Patrick Cory, the character who is keeping the brain alive.
The novel has been filmed on several occasions, most notably as The Lady and the Monster (1944) and Donovan's Brain (1953), the latter starring Nancy Reagan.