Docosanol
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Docosanol
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| Systematic (IUPAC) name | |
| docosan-1-ol | |
| Identifiers | |
| CAS number | |
| ATC code | D06 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C22H46O |
| Mol. mass | 326.6 g/mol |
| Synonyms | benehic alcohol, benehyl alcohol, docosyl alcohol, n-docosanol |
| Physical data | |
| Melt. point | 71 °C (160 °F) |
| Boiling point | 180 °C (356 °F) |
| Pharmacokinetic data | |
| Bioavailability | Not absorbed |
| Metabolism | N/A |
| Half life | N/A |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status | |
| Routes | Topical |
Docosanol is a drug used for topical treatment for recurrent herpes simplex labialis episodes (episodes of cold sores or fever blisters). A saturated 22-carbon aliphatic alcohol, docosanol exhibits antiviral activity against many lipid enveloped viruses including herpes simplex virus (HSV). Docosanol inhibits fusion between the plasma membrane and the herpes simplex virus (HSV) envelope, thereby preventing viral entry into cells and subsequent viral replication.
Abreva is the brand name of a cream containing 10% Docosanol. Abreva is the first over-the-counter anti-viral drug approved for sale in the United States.
[edit] External links
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| Anti-herpesvirus | Aciclovir, Cidofovir, Docosanol, Famciclovir, Fomivirsen, Foscarnet, Ganciclovir, Idoxuridine, Penciclovir, Trifluridine, Tromantadine, Valaciclovir, Valganciclovir, Vidarabine |
| Anti-influenza agents | Amantadine, Arbidol, Oseltamivir, Peramivir, Rimantadine, Zanamivir |
| Antiretrovirals: NRTIs | Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Zalcitabine, Zidovudine |
| Antiretrovirals: NtRTIs | Tenofovir |
| Antiretrovirals: NNRTIs | Efavirenz, Delavirdine, Nevirapine, Loviride |
| Antiretrovirals: PIs | Amprenavir, Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Nelfinavir, Ritonavir, Saquinavir, Tipranavir |
| Antiretrovirals: Fusion inhibitors | Enfuvirtide |
| Other antiviral agents | Adefovir, Fomivirsen, Imiquimod, Inosine, Interferon, Podophyllotoxin, Ribavirin, Viramidine |
