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The Disputation of the Holy Sacrament (Italian: La disputa del sacramento), or La Disputa, is a painting by the Italian renaissance artist Raphael. It was painted between 1509 and 1510 as the first part of Raphael's commission to decorate with frescoes the rooms that are now known as the Stanze di Raffaello, in the Apostolic Palace in the Vatican.
In the painting, Raphael has created an image of the church, which is presented as spanning both heaven and earth. Above, Christ is surrounded by the Blessed Virgin Mary, John the Baptist and various biblical figures such as Adam, Moses and Jacob. Below, Christ's body is represented in the eucharist, which is discussed by representatives of the Church; among them are Pope Julius II, Pope Sixtus IV, Savonarola and Dante Alighieri.
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