Dipeptidyl peptidase-4

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Ribbon diagram of human DPP-4. From PDB 1PFQ.
dipeptidyl-peptidase 4
Identifiers
Symbol	DPP4 CD26, ADCP2
HUGO	3009
Entrez	1803
OMIM	102720
RefSeq	NM_001935
UniProt	P27487
Other data
EC number	3.4.14.5
Locus	Chr. 2 q23-qter

Dipeptidyl peptidase-4 is an enzyme associated with glucose metabolism. Specifically, it is responsible for the degradation of incretins such as GLP-1.

A new class of oral hypoglycemics called dipeptidyl peptidase-4 inhibitors work by inhibiting the action of this enzyme, thereby prolonging incretin effect in vivo:

[edit] External links

• MeSH Dipeptidyl-Peptidase+IV
• Banting and Best Diabetes Centre at UT dp_iv