Digitonin
From Wikipedia, the free encyclopedia
Digitonin is a glycoside obtained from Digitalis purpurea; the aglycone is digitogenin which is bound to five sugars. Used as a detergent, it effectively water-solubilizes lipids. As such, it has several membrane-related applications in biochemistry, including solubilizing membrane proteins, precipitating cholesterol, and permeabilizing cell membranes.
Digitonin is sometimes confused with the cardiac drug digoxin (sometimes also called digitalis or digitoxin), but has no heart-related effects.
[edit] Physical & Chemical Proterties
Chemical Formula= C56H92O29
Molecular Weight= 1229.3
Appearance = White to off-white powder
Boiling Point/Melting Point= 2300C to 2400C
Specific Rotation= -47 TO -49º (10 g/100 ml 75% Acetic Acid at 25 °C)1
Aggregation number = 60.
[edit] Biological Properties
Rat-LD50 : 4 mg/kg body weight
[edit] External links
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| Major Families of Biochemicals | ||
| Peptides | Amino acids | Nucleic acids | Carbohydrates | Lipids | Terpenes | Carotenoids | Tetrapyrroles | Enzyme cofactors | Steroids | Flavonoids | Alkaloids | Polyketides | Glycosides | ||
| Analogues of nucleic acids: | Types of Glycosides | Analogues of nucleic acids: |
| Bond: | O-glycosidic bond | S-glycosidic bond | N-glycosidic bond | |
|---|---|---|
| Geometry: | α-Glycoside | β-Glycoside | 1,4-Glycoside | 1,6-Glycoside | |
| Glycone: | Glucoside | Fructoside | Glucuronide | |
| Aglycone: | Alcoholic glycoside | Anthraquinone glycoside | Coumarin glycoside | Cyanogenic glycoside | Flavonoid glycoside | Phenolic glycoside | Saponin | Cardiac glycoside | Steviol glycoside | Thioglycoside | Glycosylamine | Bufanolide | Cardenolide | |
