Talk:Diclofenac

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Question: Is there some connection between taking Diclofenac and menstrual bleeds in post menopausal women taking non-bleed HRT? I would be very interested to get some feed back. Catherine

I don't see an association to HRT, as non-bleed HRT is said to normally increase coagulation tendencies. But Diclofenac may infrequently cause gynecological bleedings, either due to thrombocytopenia or due to direct inhibition of thrombocytic aggregation, alone or with other anticoagulants (low dose Aspirin, Heparine, coumarines). Do you take one of those? Perhaps, you should ask for laboratory examinations, if the bleeds occur again or if you have other symptoms (skin bleeding, unusual fatigue etc.). Diclofenac can have a great number of serious side-effects during longterm treatment, so you should consider to terminate Diclofenac if possible. For pain often Acetaminophen is a good alternative. Your doctor will know. I would be interested to hear from you again what happened.

Best of luck. Klaus

I find the comment about the decline in the vulture population hilarious. I find difficult to believe that so many vultures would die for this reason. But I really do not know. --Anagnorisis 18:38, 28 October 2005 (UTC)

Well, I would not have included it if this paper had not been in Nature and cited by Bandolier. JFW | T@lk 01:20, 30 October 2005 (UTC)

A little research would have told you it's anything but hilarious. Indeed, it was well reported in the media [1] at the time, too. James 15:52, 12 November 2006 (UTC)

[edit] diclofenac

What are the difference between the diclofenac sodium and diclofenac potassium?

—The preceding unsigned comment was added by 82.114.160.33 (talk • contribs). 20:13, 6 August 2006

Good question - I think it affects uptake rate - Diclofenac sodium is sparingly soluble in water while diclofenac potassium is very soluble in water [2]. There does not seem to be a significant difference in pain relief between the two salts [3]. Perhaps there are also implications for the Na/K balance in the body? James 15:39, 21 November 2006 (UTC)

[edit] Cardiovascular side-effects

Recent news item for consideration: http://www.nature.com/news/2006/060911/full/060911-6.html (Nature News, 13 September 2006). --User:Ceyockey (talk to me) 13:57, 16 September 2006 (UTC)