Diamond (dog)
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Diamond was Sir Isaac Newton's favorite dog, which, by upsetting a candle, set fire to manuscripts containing his notes on experiments conducted over a course of twenty years. According to one account, Newton is said to have exclaimed: "O Diamond, Diamond, thou little knowest the damage thou hast done" (or alternatively "O Diamond, Diamond, how little knowest thou the mischief thou hast done").
See also List of historical dogs.