Diacylglycerol lipase

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Diacylglycerol lipase

Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol. Two separate gene products of DGL have been identified and termed DGLα and DGLβ.

Inhibitors

The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.

[edit] References

  • Bisogno, T. et al. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. J. Cell. Biol. 2003 (163)3:463. Article
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