Desflurane

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Desflurane
Systematic (IUPAC) name
2-(difluoromethoxy)-1,1,1,2-tetrafluoro-ethane
Identifiers
CAS number 57041-67-5
ATC code N01AB07
PubChem 42113
DrugBank APRD00907
Chemical data
Formula C3H2F6O 
Mol. mass 168.038 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism Not metabolized
Half life Elimination dependent on minute ventilation
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Inhalation

Desflurane (2-(difluoromethoxy)-1,1,1,2-tetrafluoro-ethane) is a highly fluorinated methyl ethyl ether used for maintenance of general anaesthesia. Together with sevoflurane, it is gradually replacing isoflurane for human use, except in the third world where its high cost precludes its use. It has the most rapid onset and offset of the volatile anaesthetic drugs used for general anaesthesia due to its low solubility in blood.

The major drawbacks of desflurane are its low potency, its pungency and its high cost. It may cause tachycardia and airway irritability when administered at concentrations greater than 1 MAC.

Though it vaporises very readily, it is a liquid at room temperature. Anaesthetic machines use an unusual anaesthetic vaporiser that heats it to generate a gas.

[edit] Physical properties

Boiling point : 23.5 °C (at 1 atm)
Density : 1.465 g/cm³ (at 20 °C)
Molecular Weight : 168
Vapor pressure: 88.5 kPa 672 mmHg (at 20 °C)
107 kPa 804 mmHg (at 24 °C)
Blood:Gas partition coefficient : 0.42
Oil:Gas partition coefficient : 19
MAC : 6 vol %

[edit] Book reference

Eger, Eisenkraft, Weiskopf. The Pharmacology of Inhaled Anesthetics. 2003.


[edit] External links


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