Depo-Provera

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Please see the discussion on the talk page.
This article is about the contraceptive injection. For the band formerly known as DEPOPROVERA, see Depo (band).


Depo-Provera
Background
B.C. type Hormonal
First use 1967
Failure rates (per year)
Perfect use 0.3%
Typical use 0.3%
Usage
Duration effect 90 days
(12weeks + 5 days)
Reversibility 3-18 months
User reminders Maximum interval is just under 3 months
Clinic review 12 weeks
Advantages
Periods Usually no periods from 2nd injection
Benefits Especially if poor pill compliance.
Reduced endometrial cancer risk.
Disadvantages
STD protection No
Periods Especially in 1st injection may be frequent spotting
Weight gain Yes
Risks Reduced bone density
Medical notes
For those intending to start family, suggest switch 6 months prior to alternative method (eg POP) allowing more reliable return fertility.

Depo-Provera is a contraceptive or birth control product which is injected every 3 months.

It is the brand name for a depot formulation of medroxyprogesterone acetate manufactured by Pfizer Inc. It is a hormonal birth control method containing the pregnane (17α-hydroxyprogesterone derivative) progestin medroxyprogesterone acetate, without estrogen, and is administered to women in the form of an intramuscular injection once every 11 to 13 weeks. Depo-Provera causes the ovaries to stop releasing eggs.

Contents

[edit] Mechanism

The mechanism of action of progestin-only contraceptives depends on the progestin activity and dose.[1][2] High dose progestin-only contraceptives, such as injectable Depo-Provera, completely inhibit follicular development and ovulation. Like all progestin-only contraceptives, Depo-Provera also increases cervical mucus viscosity, thereby inhibiting sperm penetration. In anovulatory cycles using progestin-only contraceptives, the endometrium is thin and atrophic. If the endometrium was also thin and atrophic during an ovulatory cycle, this could theoretically interfere with implantation of a blastocyst (embryo).

[edit] Failure Rates

Most sources cite the failure rate for Depo-Provera at 0.3 percent annually, which would be three women out of a thousand per year.[3] This number is based on large prospective clinical trials of women actually using Depo-Provera. Another method of determining efficacy is based on retrospective surveys that rely on a woman's recall of her contraceptive use over the past 4 to 5 years, such as the National Surveys of Family Growth (NSFG) -- a primary source of data used for estimating user-dependent contraceptive failure rates in the United States. The number of women in the NSFG retrospective survey using Depo-Provera, Norplant, and IUDs is small, much smaller then number of women in the prospective clinical trials that evaluated the effectiveness of Depo-Provera, Norplant, and IUDs. NSFG survey data may uncover more realistic failure rates for user-dependent contraceptive methods, but has been found to produce unrealistically high failure rates for contraceptive methods that are not user-dependent (this has been attributed to contraceptive overreporting).[4] For example, NSFG survey data combined from 1988 and 1995 for Depo-Provera, Norplant, and IUDs produced a combined standardized failure rate for these three methods of 3.2 per year. Higher rates (combining Depo-Provera, Norplant, and IUD use) for women aged 20-24 (5.1 percent) and for cohabiting couples (6.5 percent). The two year combined failure rate for Depo-Provera, Norplant, and IUD use for women aged 20-24 was 10.9 percent, which comes out to one woman in ten. [5]

[edit] Benefits

Depo-Provera has several advantages:[6][7][3][8]

  • Highly effective at preventing pregnancy.
  • Injected every 3 months. The only continuing action is to book subsequent follow-up injections every twelve weeks, and to monitor side effects to insure that they do not require medical attention.
  • Culturally acceptable. Some cultures believe injections are especially efficacious. Injections also afford privacy because use is not detectable.
  • Decreased risk of endometrial cancer. Depo-Provera reduces the risk of endometrial cancer by 80%.[9][10][11] The reduced risk of endometrial cancer in Depo-Provera users is thought to be due to both the direct anti-proliferative effect of progestogen on the endometrium and the indirect reduction of estrogen levels by suppression of ovarian follicular development.[12]

[edit] Pregnancy and breastfeeding

Depo-Provera may be used by breast-feeding mothers. Heavy bleeding is possible if given in the immediate postpartum time and is best delayed until six weeks after birth. It may be used within five days if not breast feeding. While a study showed "no significant difference in birth weights or incidence of birth defects" and "no significant alternation of immunity to infectious disease caused by breast milk containing DMPA", a subgroup of babies whose mothers started Depo-Provera at 2 days postpartum had a 75% higher incidence of doctor visits for infectious diseases during their first year of life.[14]

A larger study with longer follow-up concluded that "use of DMPA during pregnancy or breastfeeding does not adversely affect the long-term growth and development of children". This study also noted that "children with DMPA exposure during pregnancy and lactation had an increased risk of suboptimal growth in height," but that "after adjustment for socioeconomic factors by multiple logistic regression, there was no increased risk of impaired growth among the DMPA-exposed children." The study also noted that effects of DMPA exposure on puberty require further study, as so few children over the age of 10 were observed.[15]

[edit] Disadvantages and side effects

[edit] Warnings and precautions

  • Depo-Provera can require up to fourteen days to take effect. This means pregnancy can occur within fourteen days of the first Depo injection.
  • Takes seven days to take effect if given after the first four days of the period cycle. Effective immediately if given during the first four days of the period cycle.
  • Depo-Provera can affect menstrual bleeding. After a year of use, 55% of women experience amenorrhoea; after 2 years, the rate rises to 68%. In the first months of use "irregular or unpredictable bleeding or spotting, or rarely, heavy or continuous bleeding" was reported.[16]
  • Delayed return of fertility. The average return to fertility is 9 to 10 months after the last injection. By 18 months after the last injection, fertility is the same as that in former users of other contraceptive methods[3][8]
  • Long-term studies of users of Depo-Provera have found slight or no increased overall risk of breast cancer. However, the study population did show a slightly increased risk of breast cancer in recent users (Depo use in the last four years) under age 35, similar to that seen with the use of combined oral contraceptive pills.[16]
  • Infants born to women exposed to Depo during pregnancy in one study had an 80% greater chance of dying in the first year of life.[17]

[edit] Black box warning

While it has long been known that Depo-Provera causes bone loss, it has recently been discovered that the osteoporotic effects of the injection grow worse the longer Depo-Provera is administered, may remain long after the injections are stopped, and may be irreversible. For this reason, on November 17, 2004 the United States Food and Drug Administration and Pfizer agreed to put a "black box warning" on Depo-Provera's label.[18] However, the World Health Organization (WHO) advises that the use of Depo-Provera should not be restricted.[19][20]

It is unclear whether the bone density loss associated with Depo-Provera use is reversible, and if so, how completely. Three studies have suggested that bone loss is reversible after the discontinuation of Depo-Provera, although one notes that bone loss was not reversible in long-term users of Depo-Provera.[21][22][23] Other studies have suggested that the effect of Depo-Provera use on post-menopausal bone density is minimal,[24] perhaps because Depo users experience less bone loss at menopause.[25] However, as of 2006, no study has directly examined fracture risk in post-menopausal women who have used Depo-Provera; therefore, the risk is unknown. Pfizer and the FDA recommend that Depo-Provera not be used for longer than 2 years, unless there is no viable alternative method of contraception, due to concerns over bone loss.[18]

[edit] Side effects

In the largest clinical trial of Depo-Provera, the most frequently reported adverse reactions (which may or may not be related to the use of Depo-Provera) were: menstrual irregularities (bleeding or amenorrhea or both), abdominal pain or discomfort, weight changes, headache, asthenia (weakness or fatigue), and nervousness. Other, less frequently reported adverse reactions are listed in the patient and physician label information for Depo-Provera.[16][26]

[edit] Related studies

  • A study of 819 women in one city found an association between using Depo-Provera and higher incidence of chlamydia and gonorrhea.[27] A second prospective study in 948 Kenyan women found that Depo-Provera use was associated with higher rates of chlamydial infection, but lower rates of trichomoniasis and pelvic inflammatory disease, when compared to women using no contraception.[28]
  • Primate studies of medroxyprogesterone have suggested that it may increase the risk of transmission of simian immunodeficiency virus (SIV), an animal model of HIV.[29][30] At least one study in humans has suggested an increased rate of HIV infection in Depo-Provera users,[31] while a number of other studies have found no such association.[32][33][34] A large prospective clinical trial addressing the issue of Depo-Provera and HIV susceptibility is currently ongoing.[35]

[edit] Contraindications

The WHO Medical Eligibility Criteria for Contraceptive Use and RCOG Faculty of Family Planning & Reproductive Health Care (FFPRHC) UK Medical Eligibility Criteria for Contraceptive Use list the following as conditions where use of Depo-Provera is not usually recommended or should not be used because of an unacceptable health risk or because it is not indicated:[36][37]

Conditions where the theoretical or proven risks usually outweigh the advantages of using Depo-Provera:

Conditions which represent an unacceptable health risk if Depo-Provera is used:

  • Current or recent breast cancer (a hormonally sensitive tumour)

Conditions where use of Depo-Provera is not indicated and should not be initiated:

[edit] Other uses

Depo-Provera is also used with male sex offenders as a form of chemical castration as it has the effect of drastically reducing sex drive in males.[1]

[edit] Controversy over Approval of Depo-Provera in the United States

There was a long, controversial history regarding the approval of Depo-Provera by the U.S. Food and Drug Administration. The original manufacturer, Upjohn, applied repeatedly for approval. FDA advisory committees unanimously recommended approval in 1973, 1975 and 1992, as did the FDA's professional medical staff, but the FDA repeatedly denied approval. Ultimately, on October 29, 1992, the FDA approved Depo-Provera, which had by then been used by over 30 million women since 1969 and was approved and being used by nearly 9 million women in more than 90 countries, including the United Kingdom, France, Germany, Sweden, Thailand, New Zealand and Indonesia.[38] Points in the controversy included:

  • Animal testing for carcinogenicity. Depo-Provera caused breast cancer tumors in dogs. Critics of the study claimed that dogs are more sensitive to artificial progesterone, and that the doses were too high to extrapolate to humans. The FDA pointed out that all substances carcinogenic to humans are carcinogenic to animals as well, and that if a substance is not carcinogenic it does not register as a carcinogen at high doses. Levels of Depo-Provera which caused malignant mammary tumors in dogs were equivalent to 25 times the amount of the normal luteal phase progesterone level for dogs. (Which is lower than the pregnancy level of progesterone for dogs, and is species-specific.)[2]
    Depo-Provera caused endometrial cancer in monkeys—2 of 12 monkeys tested, the first ever recorded cases of endometrial cancer in rhesus monkeys.[39] However, subsequent studies have shown that in humans, Depo-Provera actually reduces the risk of endometrial cancer by approximately 80%.[9][10][11]
    Speaking in comparative terms regarding animal studies of carcinogenicity for drugs, a member of the FDA's Bureau of Drugs testified at an agency Depo hearing, "...Animal data for this drug is more worrisome than any other drug we know of that is to be given to well people."
  • Cervical cancer in Upjohn/NCI studies. Cervical cancer was found to be increased as high as 9-fold in the first human studies recorded by the manufacturer and the National Cancer Institute.[40] However, numerous larger subsequent studies have shown that Depo-Provera use does not increase the risk of cervical cancer.[41][42][43][44][45]
  • Coercion and lack of informed consent. Testing/use of Depo was focused almost exclusively on women in developing countries and poor women of color in the US,[46] raising serious questions about coercion and lack of informed consent, particularly for the illiterate[47] and for the mentally retarded, who in some reported cases were given Depo long-term for reasons of "menstrual hygiene", in spite of the fact that they were not sexually active.[48]
  • Atlanta/Grady Study. Upjohn studied the effect of Depo for 11 years in Atlanta, mostly on black women who were receiving public assistance, but did not file any of the required follow-up reports with the FDA. Investigators who eventually visited noted that the studies were disorganized. "They found that data collection was questionable, consent forms and protocol were absent; that those women whose consent had been obtained at all were not told of possible side effects. Women whose known medical conditions indicated that use of Depo would endanger their health were given the shot. Several of the women in the study died; some of cancer, but some for other reasons, such as suicide due to depression. Over half the 13,000 women in the study were lost to followup due to sloppy record keeping." Consequently, no data from this study was usable.[46]
  • WHO Review. In 1992, the WHO presented a review of Depo in four developing countries to the FDA. The National Women's Health Network and other women's organizations testified at the hearing that the WHO was not objective, as the WHO had already distributed Depo-Provera in developing countries. Depo was approved for use in US on the basis of the WHO review of previously submitted evidence from countries such as Thailand, evidence which the FDA had deemed insufficient and too poorly designed for assessment of cancer risk at a prior hearing.[3]The Alan Guttmacher Institute has speculated that US approval of Depo may increase its availability and acceptability in developing countries.[4][49]

[edit] Aftermath

  • In 1995, several women's health groups asked the FDA to put a moratorium on Depo-Provera, and to institute standardized informed consent forms.[50]
  • In 1994, when Depo was approved in India, India's Economic and Political Weekly reported that "The FDA finally licensed the drug in 1990 in response to concerns about the population explosion in the third world and the reluctance of third world governments to license a drug not licensed in its originating country." [51] Some scientists and women's groups in India continue to oppose Depo-Provera.[52] In 2002, Depo was removed from the family planning protocol in India.[citation needed]
  • One in five black teenagers using birth control in the US uses Depo-Provera, a far higher rate of use than for white teenagers. Activists claim this is because black teenagers are disproportionately targeted for the least safe contraceptives.[53]
  • The Canadian Coalition on Depo-Provera, a coalition of women's health professional and advocacy groups, opposed the approval of Depo in Canada.[54] Since the approval of Depo in Canada in 1997, a $700 million class-action lawsuit has been filed against Pfizer by users of Depo who developed osteoporosis. In response, Pfizer argued that it had met its obligation to disclose and discuss the risks of Depo-Provera with the Canadian medical community.[55]

[edit] Footnotes

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  2. ^ Loose, Davis S.; Stancel, George M. (2006). "Estrogens and Progestins", in in Brunton, Laurence L.; Lazo, John S.; Parker, Keith L. (eds.): Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th ed., New York: McGraw-Hill, pp. 1541-1571. ISBN 0-07-142280-3. 
  3. ^ a b c Hatcher, Robert A. (2004). "Depo-Provera Injections, Implants, and Progestin-Only Pills (Minipills)", in in Hatcher, Robert A.; Trussell, James; Stewart, Felicia H.; Nelson, Anita L.; Cates Jr., Willard; Guest, Felicia; Kowal, Deborah: Contraceptive Technology, 18th rev. ed., New York: Ardent Media, pp. 461-494. ISBN 0-9664902-5-8. 
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  5. ^ N Ranjit, A Bankole, JE Darroch, S Singh, (2001). "Contraceptive Failure in the First Two Years of Use: Differences Across Socioeconomic Subgroups". Family Planning Perspectives 33 (1): 19-27. 
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  7. ^ Mishell Jr., Daniel R. (2004). "Contraception", in in Strauss, Jerome F. III; Barbieri, Robert L. (eds.): Yen and Jaffe's Reproductive Endocrinology, 5th ed., Philadelphia: Elsevier Saunders, pp. 899-938. ISBN 0-7216-9546-9. 
  8. ^ a b Speroff, Leon; Darney, Philip D. (2005). "Injectable Contraception", A Clinical Guide for Contraception, 4th ed., Philadelphia: Lippincott Williams & Wilkins, pp. 201-220. ISBN 0-7817-6488-2. 
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  19. ^ World Health Organization (September 2005). Hormonal contraception and bone health. Family Planning. Retrieved on May 12, 2006.
  20. ^ Curtis KM, Martins SL (2006). "Progestogen-only contraception and bone mineral density: a systematic review". Contraception 73 (5): 470-87. PMID 16627031. 
  21. ^ Cundy T, Cornish J, Evans M, Roberts H, Reid I (1994). "Recovery of bone density in women who stop using medroxyprogesterone acetate.". BMJ 308 (6923): 247-8. PMID 8111260. 
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  25. ^ Cundy T, Cornish J, Roberts H, Reid I (2002). "Menopausal bone loss in long-term users of depot medroxyprogesterone acetate contraception.". Am J Obstet Gynecol 186 (5): 978-83. PMID 12015524. 
  26. ^ Pfizer (November 2004). Depo-Provera Contraceptive Injection, US physician information. Retrieved on February 21, 2007.
  27. ^ Morrison CS, Bright P, Wong EL, Kwok C, Yacobson I, Gaydos CA, Tucker HT, Blumenthal PD (2004). "Hormonal contraceptive use, cervical ectopy, and the acquisition of cervical infections". Sex Transm Dis 31 (9): 561-7. PMID 15480119. 
  28. ^ Baeten J, Nyange P, Richardson B, Lavreys L, Chohan B, Martin H, Mandaliya K, Ndinya-Achola J, Bwayo J, Kreiss J (2001). "Hormonal contraception and risk of sexually transmitted disease acquisition: results from a prospective study.". Am J Obstet Gynecol 185 (2): 380-5. PMID 11518896. 
  29. ^ Preston A. Marx, et al. (1996). "Progesterone implants enhance SIV vaginal transmission and early virus load.". Nature Medicine 2 (10): 1084-9. DOI:10.1038/nm1096-1084. PMID 8837605. 
  30. ^ Trunova N et al (2006). "Progestin-based contraceptive suppresses cellular immune responses in SHIV-infected rhesus macaques". Virology 352 (1). PMID 16730772. 
  31. ^ Martin H, Nyange P, Richardson B, Lavreys L, Mandaliya K, Jackson D, Ndinya-Achola J, Kreiss J (1998). "Hormonal contraception, sexually transmitted diseases, and risk of heterosexual transmission of human immunodeficiency virus type 1.". J Infect Dis 178 (4): 1053-9. PMID 9806034. 
  32. ^ Bulterys M, Chao A, Habimana P, Dushimimana A, Nawrocki P, Saah A (1994). "Incident HIV-1 infection in a cohort of young women in Butare, Rwanda.". AIDS 8 (11): 1585-91. PMID 7848595. 
  33. ^ Kiddugavu M, Makumbi F, Wawer M, Serwadda D, Sewankambo N, Wabwire-Mangen F, Lutalo T, Meehan M, Gray R (2003). "Hormonal contraceptive use and HIV-1 infection in a population-based cohort in Rakai, Uganda.". AIDS 17 (2): 233-40. PMID 12545084. 
  34. ^ "Prospective study of hormonal contraception and women's risk of HIV infection in South Africa.". Int J Epidemiol. PMID 17175547. 
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  36. ^ WHO (2004). "Progestogen-only contraceptives", Medical Eligibility Criteria for Contraceptive Use, 3rd ed., Geneva: Reproductive Health and Research, WHO. ISBN 92-4-156266-8. 
  37. ^ FFPRHC (2006). The UK Medical Eligibility Criteria for Contraceptive Use (2005/2006). Retrieved on January 11, 2007.
  38. ^ Leary, Warren E. (October 30, 1992). "U.S. Approves Injectable Drug As Birth Control". The New York Times. PMID 11646958. 
  39. ^ Amy Goodman (February/March 1985). "The Case Against Depo-Provera - Problems in the U.S.". Multinational Monitor Volume 6 (Numbers 2 & 3). 
  40. ^ (1977) "Controversy over Depo-Provera.". Wash Drug Device Lett 9 (1): 2. PMID 12335988. 
  41. ^ Thomas D, Ye Z, Ray R (1995). "Cervical carcinoma in situ and use of depot-medroxyprogesterone acetate (DMPA). WHO Collaborative Study of Neoplasia and Steroid Contraceptives.". Contraception 51 (1): 25-31. PMID 7750280. 
  42. ^ (1992) "Depot-medroxyprogesterone acetate (DMPA) and risk of invasive squamous cell cervical cancer. The WHO Collaborative Study of Neoplasia and Steroid Contraceptives.". Contraception 45 (4): 299-312. PMID 1387601. 
  43. ^ Thomas D, Ray R (1995). "Depot-medroxyprogesterone acetate (DMPA) and risk of invasive adenocarcinomas and adenosquamous carcinomas of the uterine cervix. WHO Collaborative Study of Neoplasia and Steroid Contraceptives.". Contraception 52 (5): 307-12. PMID 8585888. 
  44. ^ Shapiro S, Rosenberg L, Hoffman M, Kelly J, Cooper D, Carrara H, Denny L, du Toit G, Allan B, Stander I, Williamson A (2003). "Risk of invasive cancer of the cervix in relation to the use of injectable progestogen contraceptives and combined estrogen/progestogen oral contraceptives (South Africa).". Cancer Causes Control 14 (5): 485-95. PMID 12946044. 
  45. ^ Kaunitz A (1996). "Depot medroxyprogesterone acetate contraception and the risk of breast and gynecologic cancer.". J Reprod Med 41 (5 Suppl): 419-27. PMID 8725705. 
  46. ^ a b >Karen Hawkins, Jeff Elliott (May 5, 1996). Seeking Approval. Albion Monitor. Retrieved on November 20, 2006.
  47. ^ (1973) "Sterilization of minors leads to controversy.". JOICFP Rev 2 (4): 77-8. PMID 12257656. 
  48. ^ Egan T, Siegert R, Fairley N (1993). "Use of hormonal contraceptives in an institutional setting: reasons for use, consent and safety in women with psychiatric and intellectual disabilities.". N Z Med J 106 (961): 338-41. PMID 8341476. 
  49. ^ Singh S (1995). "Adolescent knowledge and use of injectable contraceptives in developing countries.". J Adolesc Health 16 (5): 396-404. PMID 7662691. 
  50. ^ (1995) "Clinicians clash with consumer groups over possible Depo ban.". Contracept Technol Update 16 (1): 11-4. PMID 12319319. 
  51. ^ (1994) "Contraceptives. Case for public enquiry.". Economic and Political Weekly 29 (15). Popline database document number 096527. 
  52. ^ Sorojini, NB (Jan-Mar 2005). "Why women's groups oppose injectable contraceptives". Indian Journal of Medical Ethics 13 (1). 
  53. ^ Moira Brennan (April*May 2001). Dorothy Roberts: What we talk about when we talk about reproductive rights. Ms Magazine. Retrieved on August 22, 2006.
  54. ^ Madeline Boscoe (December 6 1991). Canadian Coalition on Depo-Provera letter to The Honorable Benoit Bouchard, National Minister of Health and Welfare. Canadian Women's Health Network. Retrieved on August 22, 2006.
  55. ^ Class action suit filed over birth control drug. CTV.ca (Dec 19 2005). Retrieved on August 22, 2006.

[edit] External links


Birth control edit
Sterilization: Tubal ligation, Vasectomy, Essure
Post-intercourse: Abortion: Surgical, Medical
Emergency contraception
Intra-uterine: IUD, IUS (progestogen)
Anti-estrogen: Ormeloxifene (a.k.a. Centchroman)
Hormonal: Combined: COCP ('the Pill'), Patch, Nuvaring
Progestogen only: POP mini-pill, Depo Provera, Norplant, Implanon
Barrier: Male condom, Female condom, Diaphragm, Shield, Cap, Sponge, Spermicide
Behavioral: Coitus interruptus, Rhythm Method, Lactational, Fertility awareness
Avoiding vaginal intercourse: Anal sex, Oral sex, Outercourse, Masturbation, Abstinence
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