Death Inducing Signaling Complex

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The Death Inducing Signaling Complex or DISC is a multi-protein complex formed by members of the death receptor family of apoptosis-inducing cellular receptors. The typical example is FasR, which forms the DISC upon trimerization as a result of its ligand (FasL) binding. Dogma states that the DISC is composed of the death receptor, FADD, and caspase-8. It transduces a downstream signal cascade resulting in apoptosis.

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Signal transduction, carrier proteins: adaptor proteins

14-3-3 - Caveolin - Cortactin - Death Inducing Signaling Complex - Interferon regulatory factors - Paxillin - PIAS - SMAD - SOCS - STAT (STAT1, STAT3, STAT5)

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