Daflon 500
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DAFLON 500 is also distributed as: Detralex, Arvenum 500, Alvenor, Ardium, Capiven, Elatec and Venitol
DAFLON 500 abridged prescribing information
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[edit] Presentation and Composition:
Micronized Purified Flavonoid Fraction 500mg: diosmin 450 mg, flavonoids expressed as hesperidin 50 mg.
[edit] Therapeutic properties:
Vascular protector and venotonic. DAFLON 500 mg acts on the return vascular system: it reduces venous distensibility and venous stasis; in the microcirculation, it normalizes capillary permeability and reinforces capillary resistance.
[edit] Pharmacokinetics:
Micronization of Daflon 500mg increases its gastrointestinal absorption compared with nonmicronized diosmin (urinary excretion 57.9% vs 32.7%).
[edit] Therapeutic indications:
Treatment of organic and idiopathic chronic venous disease of the lower limbs with the following symptoms: heavy legs, pain, nocturnal cramps, edema. Treatment of hemorrhoids and acute hemorrhoidal attacks.
[edit] Side effects:
Some cases of minor gastrointestinal and autonomic disorders have been reported, but these never required cessation of treatment.
[edit] Drug interactions:
None
[edit] Precautions:
Pregnancy: experimental studies in animal have not demonstrated any teratogenic effects and no harmful effects have been reported in man to date. Lactation: in the absence of data concerning the diffusion into breast milk, breast-feeding is not recommended during treatment.
[edit] Contraindications:
None
[edit] Dosage and administration:
In chronic venous disease: 2 tablets daily. In hemorrhoidal disease: - Acute crisis: 6 tablets daily for 4 days, then 4 tablets daily for 3 days. - Chronic treatment: 2 tablets daily.
