Cytokine receptor

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Key steps of the JAK-STAT pathway
Key steps of the JAK-STAT pathway

A Cytokine receptor is a receptor which binds cytokines.

Members of the type I and type II cytokine receptor families possess no catalytic kinase activity, they rely on the Janus kinase (JAK) family of tyrosine kinases to phosphorylate and activate downstream proteins involved in their signal transduction pathways.

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Transmembrane receptors: immune receptors

Antigen receptor (B-cell receptor, T cell receptor) - Complement - Fc (FcεRI, FcεRII) - Formyl peptide - Immunophilins - Integrin - Lymphocyte homing receptor (CD44, L-selectin, Integrin alpha4beta1, LFA-1) - Pattern recognition/Toll-like (TLR 2, TLR 3) - Scavenger

Cytokine receptors: Type I (IL-2, IL-3) - Type II - Glycoprotein 130 - Chemokine receptor - TGF-beta receptors


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