Cyproheptadine

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Cyproheptadine
Systematic (IUPAC) name
4-(5 H-dibenzo [a,d]cyclohepten-5-ylidene)- 1 -methylpiperidine hydrochloride
Identifiers
CAS number	129-03-3
ATC code	R06AX02
PubChem	2913
DrugBank	APRD00033
Chemical data
Formula	C21H21N
Mol. mass	287.398 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	96 to 99%
Metabolism	Hepatic/Renal
Half life	1-4 hours
Excretion	Fecal/Renal
Therapeutic considerations
Pregnancy cat.	B (USA)
Legal status	Prescription
Routes	Oral only

Periactin® (cyproheptadine hydrochloride) is an antihistaminic and antiserotonergic agent. It acts as a 5-HT2 receptor antagonist and also blocks calcium channels.

[edit] Uses

Cyproheptadine is used in the treatment of allergies (specifically Hay fever) and is also used to stimulate appetite in underweight people (e.g. anorexia nervosa).

Cyproheptadine may also be used to combat SSRI-induced sexual dysfunction, but is used cautiously in this manner due to the fact that it may reverse the effects of the SSRI.

Cyproheptadine is also used for the treatment of Cushing's Syndrome, the treatment of serotonin reactions secondary to meperidine, and may be used, though rarely, as a prophylactic drug for migraine headaches.

[edit] Side effects

While not specifically used as a sedative, cyproheptadine causes sedation, likely due to its anti-histamine effects.

v • d • e Antihistamines (primarily R06)
Aminoalkyl ethers	Bromazine, Carbinoxamine, Clemastine, Chlorphenoxamine, Diphenylpyraline, Diphenhydramine, Doxylamine
Substituted alkylamines	Brompheniramine, Chlorphenamine, Dexbrompheniramine , Dexchlorpheniramine, Dimetindene, Pheniramine, Talastine
Substituted ethylene diamines	Chloropyramine, Histapyrrodine, Mepyramine, Methapyrilene,Pyribenzamine
Phenothiazine derivatives	Alimemazine, Hydroxyethylpromethazine, Isothipendyl, Mequitazine, Methdilazine, Oxomemazine, Promethazine
Piperazine derivatives	Buclizine, Cetirizine, Chlorcyclizine, Cinnarizine, Cyclizine, Hydroxyzine, Levocetirizine, Meclozine, Niaprazine, Oxatomide
Others for systemic use	Acrivastine, Antazoline, Astemizole, Azatadine, Azelastine, Bamipine, Cyproheptadine, Deptropine, Desloratadine, Ebastine, Epinastine, Ketotifen, Loratadine, Mebhydrolin, Mizolastine, Phenindamine, Pimethixene, Pyrrobutamine, Rupatadine, Terfenadine, Triprolidine
For topical use	Bamipine, Chloropyramine, Chlorphenoxamine, Clemastine, Dimetindene, Diphenhydramine, Isothipendyl, Mepyramine, Promethazine, Thenalidine
Antiallergic agents excluding corticosteroids	Antazoline, Azelastine, Fexofenadine
Other antiallergics	Emedastine, Epinastine, Ketotifen, Olopatadine