CYP2E1

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Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are some important drug interactions mediated by CYP2E1.

[edit] CYP2E1 Ligands

Selected inducers, inhibitors and substrates of CYP2E11
Type Agent
inducers acetone, ethanol, isoniazid
inhibitors cimetidine, disulfiram, (isoniazid)?
substrates anaesthetics (halothane, isoflurane, etc), dapsone, paracetamol (acetaminophen), theophylline
Notes:
  1. Where classes of agents are listed, there may be exceptions within the class.


cytochrome P450, family 2, subfamily E, polypeptide 1
Identifiers
Symbol CYP2E1 CYP2E
HUGO 2631
Entrez 1571
OMIM 124040
RefSeq NM_000773
UniProt P05181
Other data
Locus Chr. 10 q24.3-qter

[edit] See also

v • d • e
Oxidoreductases: oxygenases (EC 1.13, 14)

Monooxygenases: 4-Hydroxyphenylpyruvate dioxygenase - Firefly luciferase

Dioxygenases: Aromatase - Nitric oxide synthase - CYP2D6 - CYP2E1 - CYP3A4 - Phenylalanine hydroxylase - Tryptophan hydroxylase - Tyrosine hydroxylase - Dopamine beta hydroxylase - Tyrosinase - Steroid hydroxylases

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