CYP17A1

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CYP17A1 (also known as 17a-hydroxylase/17,20 lyase) is a cytochrome P450 oxidase enzyme which acts upon pregnenolone and progesterone to add a hydroxyl ("-OH") group at carbon 17 of the "D" ring (the hydroxylase activity), or acts upon 17-hydroxy progesterone and 17-hydroxy pregnenolone to split the side chain off the steroid nucleus (the lyase activity).

17α-hydroxylase converts pregnenolone and progesterone to their 17-hydroxy forms, and converts 17-hydroxy pregnenolone and 17-hydroxy progesterone to DHEA and androstenedione, respectively. It corresponds to the downward arrows in this reaction scheme.

[edit] Additional images

Pregnenolone	17-Hydroxypregnenolone	Progesterone	17-Hydroxyprogesterone
Steroidogenesis	Steroid numbering

[edit] See also

• Congenital adrenal hyperplasia due to 17 alpha-hydroxylase deficiency

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