CXCL16

From Wikipedia, the free encyclopedia

chemokine (C-X-C motif) ligand 16
Identifiers
Symbol	CXCL16 SCYB16, SR-PSOX, CXCLG16
HUGO	16642
Entrez	58191
OMIM	605398
RefSeq	NM_022059
UniProt	Q9H2A7
Other data
Locus	Chr. 17 p13

Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small cytokine belonging to the CXC chemokine family. Larger than other chemokines (with 254 amino acids), CXCL16 is composed of a CXC chemokine domain, a mucin-like stalk, a transmembrane domain and a cytoplasmic tail containing a potential tyrosine phosphorylation site that may bind SH2.^[1] These are unusual features for a chemokine, and allow CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine.^[2] CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen.^[1] Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells.^[1] CXCL16 interacts with the chemokine receptor CXCR6, also known as Bonzo.^[3]^[1] Expression of CXCL16 is induced by the inflammatory cytokines IFN-gamma and TNF-alpha.^[2] The gene for human CXCL16 is located on chromosome 17.^[1]

[edit] References

^ ^a ^b ^c ^d ^e Matloubian M, David A, Engel S, Ryan J, Cyster J (2000). "A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo". Nat Immunol 1 (4): 298-304. PMID 11017100.
^ ^a ^b Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout T, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen K, Saftig P, Rose-John S, Ludwig A (2004). "The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10". J Immunol 172 (10): 6362-72. PMID 15128827.
^ Wilbanks A, Zondlo S, Murphy K, Mak S, Soler D, Langdon P, Andrew D, Wu L, Briskin M (2001). "Expression cloning of the STRL33/BONZO/TYMSTRligand reveals elements of CC, CXC, and CX3C chemokines". J Immunol 166 (8): 5145-54. PMID 11290797.