Talk:Creatinine

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On the lines that follow in this article. Are the units supposed to be mg/dL instead of md/dL?

While a baseline serum creatinine of 2.0 md/dL may indicate normal kidney function in a male body builder, a serum creatinine of 0.7 md/dL can indicate significant renal disease in a frail old woman"

They are. Just a typo on my part. I've fixed it. Richardsur 23:36, 23 Aug 2004 (UTC)

Anybody know if μmol/L is really the SI unit of creatinine? I thought the differences were more based on region than anything else since mg/dL also uses SI/metric units. Richardsur 23:49, 23 Aug 2004 (UTC)

According to the JAMA instruction to authors the SI units for creatinine are µmol/L. 

To convert use the following: Creatinine 1 mg/dL = 88.4 µmol/L

Are the reference ranges for serum (or e.g. urinary) creatinine?

[edit] Sports medicine

Elevated creatinine levels due to supplemental creatine might result in mis-diagnosis. Most doctors (general practitioners) appear unaware of creatine as a body building supplement. They are apt to diagnose non-existent kidney conditions in healthy patients taking creatine supplements. Mention should be made, under Diagnostic Use, of supplemental creatine as a possible source of elevated creatinine levels in healthy individuals. Mseslacker 21:39, 4 March 2007 (UTC)

Last line states body builders take supplemental creatine. This section is about creatinine, isn't it a different material? Dkronst 22:39, 26 May 2006 (UTC)

Yes and no. Creatinine is different, but it is the breakdown product of creatine, which is taken by bodybuilders. but the comment does seem out of place. 130.123.128.117 22:29, 25 June 2006 (UTC)

With creatine supplementation I assume one would have increased levels of creatinine. Does that actually stress the kidneys?

No. Creatinine is freely filtered at the glomerular apparatus. While increased levels in a normal individual is a sign of impaired filtering, the increased creatinine does not harm or stress the kidneys in any way. So, having a high level of creatinine is only a sign of a problem, but is not a problem. Rjkd12 21:07, 5 December 2006 (UTC)

[edit] Creatinine levels

I was diagnosed with CKD in late September. My Creatinine level is 3.0 My mother also has CKD and her Creatinine level is 3.2 She is currently in stage 4 and within months of total renal failure. My question is how high will my levels get before renal failure? I have a mesomorph body type and carry a high % of muscle mass.

[edit] why leg cramps?

why high levels cause leg cramps? what is the pathophysiological reason for this? including some biochem rxn reasons or molec cell explanations. Why in the legs and not other places? what about joint problems? what is causing the muscle pain? And then, shouldn't there be better linking to diseases and treatments to kidney problems?

Creatinine nor creatine causes cramps. This is one of the oldest myths around. Cramps are neurological in nature and have to do with muscle spindles and golgi tendon organs.

It is also freely filtered at the glomerular apparatus, so it doesn't "stress" the kidneys to excrete large amounts, nor is high levels bad at all. A high urniary creatinine level is no more indicative of renal failure than urinating a lot for a few days is indicative of having diabetes. Rjkd12 16:21, 28 February 2007 (UTC)