Cremophor EL
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Cremophor EL is polyethoxylated castor oil. Polyethoxylated castor oil is a mixture of ricinoleic acid, polyglycol ester, glyerol polyglycol esters, and polyglycols [1].
Cremophor EL is an excipient or additive in drugs. Therapeutically, modern drugs are rarely given in a pure chemical state, so most active ingredients are combined with excipients or additives such as Cremophor EL [2]
[edit] Uses
- Miconazole, anti-fungal
- Paclitaxel, anti-cancer
- Aci-Jel (acetic acid / oxyquinoline / ricinoleic acid - vaginal)
- Sandimmune (cyclosporine injection, USP)
- Nelfinavir mesylate, HIV protese inhibitor
Cremophor EL is used in Taxol (paclitaxel) and has been called as a dose limiting agent because of its toxicities. A formulation that uses nanoparticle albumin instead of Cremophor EL is marketed as an alternative.[3][4]
[edit] See also
[edit] References
- ^ Reversible Thrombocytosis and Anemia Due to Miconazole Therapy (pdf). PubMed. Retrieved on January 7, 2007. See page 1, Methods and Materials.
- ^ A new Steroid Anaaesthetic - Althesin (pdf). PubMed. Retrieved on January 7, 2007. See page 1/49, Methods and Materials.
- ^ Desai N, Yao Z, Trieu V, Soon-Shiong P, Dykes D, Noker P. Evidence of greater tumor and red cell partitioning and superior antitumor activity of Cremophor free nanoparticle paclitaxel (ABI-007) compared to taxol. Breast Cancer Res Treat. 2003;82(suppl 1):S83. Abstract 348.
- ^ O'Shaughnessy J, Tjulandin S, Davidson N, et al. ABI-007 (ABRAXANE™), a nanoparticle albumin-bound (nab) paclitaxel demonstrates superior efficacy vs taxol in metastatic breast cancer: A Phase III Trial. Breast Cancer Res Treat. 2003;82(suppl 1). Abstract 43. [1]
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