Talk:Corynebacterium diphtheriae
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Why does Crynebaterium redirect here? Shouldn't there be a page about the genus as a whole?
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[edit] "strictly human"?
I am not familiar with the terminology of this field, but the sentence at the end of the second paragraph, "It is a strictly human micro-organism", looks strange to me. I figure I am human; c. diphtheriae is not. I assume that what this really means is that c. diphtheriae only infects humans or only inhabits human body fluids. Should this be restated in one of those ways? — Nowhither 08:39, 30 August 2005 (UTC)
- The usual way would be "Corynebacterium diphtheriae is pathogenic only in humans." - Nunh-huh 08:45, 30 August 2005 (UTC)
[edit] Poorly translated test from the german wiki
The bacterium Corynebacterium diphtheriae is the exciter of the Diphtherie. Table of contents [ hide ] * 1 morphology * 2 epidemiology * 3 pathogenesis * 4 Diphtherietoxin * 5 Web on the left of
[edit] Morphology
C diphteriae is a grampositives, lobar bacterium. Because it does not possess scourges, it is immovable. It forms neither cap nor sporen. With the Neisser colouring characteristic, finalconstant finding from polyphosphates and calcium can be represented, which are called Polkoerperchen. Under the microscope the individual staebchen deposit themselves frequently v or y-foermig and remind in such a way of Chinese characters. For studies it is of importance that the Corynebacterien can be divided on the basis the average number of Polkoerperchen in biotypes. Biotype # Polkoerperchen Corynebacterium diphtheriae mitis 5 to 6 Corynebacterium diphtheriae grave 1 to 2 Corynebacterium diphtheriae intermedius 3 to 4.
[edit] Epidemiology
Because humans are that only exciter reservoir, the propagation of the bacterium can be fought by inoculation very well. There were still in 2. World war by 3 million illnesses, then is today very small the Inzidenz. In Central Europe it amounts to approx. 0,001/100000/Jahr. In the first years after the end of the USSR there was a substantial rise of the illnesses in the succession states, when the vaccination campaigns broke down. Today C diphtheriae is again successfully fought there in addition, by large-scale vaccination campaigns. In many developing countries Diphtherie remains however further a problem.
[edit] Pathogenesis
The transmission been made ducrh close contact (face ton face) with infected persons, mostly via droplets, more rarely also by contaminated articles. The exciter arrives over the mucous membrane, Konjunktiven or wounds into the body and increases there. The Diphtherietoxin, which is not formed however by all C diphtheriae, damages locally the cells, so that a pseudomembrane from died cell components in the nasopharyngeal cavity forms. If pseudomembrane on the larynx spreads can it to substantial difficulty in breathing and finally to death come. The poison works in addition in the entire body and damages there before all the heart, the kidneys, the suprarenal bodies, motor nerves and the liver. Independently of the effect of the poison also skin infections and Endokarditis were observed.
[edit] Diphtherietoxin
The genetic information for the Toxin tox+ is not in the Genom of the bacterium, but in a virus, which is often to be found diphtheriae as pro phage in C. This symbiosis is however so close that the gene dtxR, which adjusts tox+, on which Bakteriengenom to be found is. In presence of iron dtxR the production of the poison switches off. Similarly as also different Bakterientoxine the Diphtherietoxin consists of a larger B and a smaller A-part. The b-part contains a connection place, with which it itself to a protein (HB EGF precursor - heparin binding epidermal growth factor), which at human cells to be found frequent is, binds. The poison is then taken up in a vakuole to the cell, where then the A-part can split itself off. On the A-part is an enzyme, which a ADP Ribosyl transfers to the Elongationsfaktor eEF2 of NAD. Thus the Elongationsfaktor is inhibiert, it can no more RNA synthesis take place and finally dies the cell. The Diphtherietoxin is so potent with the fact that a molecule is sufficient, in order to kill a cell. The proof takes place by means of Elek test.
Will merge later Onco_p53 06:10, 6 July 2006 (UTC)
