Talk:Cortisol
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hi
This sentence needs a rewrite. I'm not sure what it's supposed to say
- Since swelling is caused by the immune system, Cortisol can help to decrease the swell and severe allergy reaction. --LeeHunter 23:32, 12 Aug 2004 (UTC)
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[edit] Should merge with hydrocortisone?
There is another less developed page entitled hydrocortisone. Obviously it deals with the same substance. Perhaps that entry should be merged with this one? KBi 03:25, 3 May 2005 (UTC)
I suppose they could be merged, as hydrocortisone is the synthetic cousin of cortisol (as far as I know)...
- According to Guyton, Hall: Textbook of Medical Physiology (p.875), these are just two names for the same substance. --Eleassar777 21:59, 29 May 2005 (UTC)
- I looked up online sources such as the NIH and they say that hydrocortisone is the synthetic version of cortisone and that is is similar, but apparently not exactly, the same. Also, some people are allergic to hydrocortisone, though that article is about the skin and perhaps you can be allergic to natural cortisone on the skin or elsewhere. I would keep the article together, as they've apparently been merged now, and simply make sure that the distinction between them is made. Kjkolb 16:46, Jun 14, 2005 (UTC)
[edit] Whoa
This article is a little scientifically intense to start off, it would be nice to have a more gentle intro. TitaniumDreads 6 July 2005 11:06 (UTC)
- Be bold. Also please source the cortisol/obesity comment with a serious reference. JFW | T@lk 6 July 2005 15:15 (UTC)
[edit] TV ads
what about the tv ads for fat people for otc meds that reduce cortisol. anyone know about info on how they do/dont work and why, & add it to the article - anonym420
- I live in a country without direct-to-consumer advertising, so we are spared this. Bottom line: they don't work. It's based on the premise that fat people have hypercortisolism, but this is not so, unless they have Cushing's disease (a rare condition compared to obesity). If these drugs worked, they'd be causing Addison's disease, which is more dangerous than Cushing's in the short term (hypotension and hypoglycemia being phenomena one would expect). JFW | T@lk 12:33, 5 September 2005 (UTC)
[edit] error ?
hello, i am not an expert, but after browsing several related topic on insulin, is there an error on the following paragraph (marked by asterisks), shouldn't the marked word be decreased instead of increased? :
"In normal release, cortisol has widespread actions which help restore homeostasis after stress. It acts as a physiological antagonist to insulin by promoting breakdown of carbohydrates, lipids, and proteins and so mobilizing energy reserves. This leads to increased blood glucose concentrations and *increased* glycogen formation in the liver (Freeman, 2002)."
- It sounds odd, but most of what I found on Google seems to support the present version. JFW | T@lk 16:41, 20 November 2005 (UTC)
You are right on the logic side but the fact is cortisol is not part of glycogen regulation. I was wondering the same thing until I saw how it goes: If there is increased blood glucose there would be increased glycogen formation. It goes well with the fact that it promotes after stress homeostasis(the epinephrine burst that decreased liver glycogen would be gone).
There are 4 major regulator of glycogen metabolism: insulin and then glucagon, epinephrine and norepinephrine; the first one resulting in increased stockage and the others in increased degradation. Stress normally induced degradation and cortisol is a stress hormone as is adrenaline(epinephrine) but it seems it is more post stress and so that could explain it.
cortisol does not increase glycogen formation and this statement needs to be removed.
[edit] Does Corticol cause Obesity?
is it true the hearing increased cortisol translates into obesity?
- Yes, see Cushing's syndrome. JFW | T@lk 10:24, 29 November 2005 (UTC)
[edit] pregnenolone
By my understanding, cortisol is synthesized from pregnenolone rather than progesterone. The steps in the cortisol synthetic pathway from cholesterol are: Cholesterol -> pregnenolone -> 17-OH pregnenolone -> 17-OH progesterone -> 11-deoxycortisol -> cortisol.
[edit] correction
I have found an alternatively described pathway that does show that cortisol can be synthesized via a progesterone intermediate. However, progesterone is first synthesized from pregnenolone, still making pregnenolone the original comitting precursor molecule for steroid hormone synthesis.
[edit] Side effects of topical application of cortisol cream
Are there any? I've found its immune-system repression is great for fighting psoriasis but I wonder if there are any long-term effects from repeated use on the same area of skin. 00:14, 5 August 2006 (UTC)
[edit] Cleanup required
I think the Physiology section is awfully messy/noisy, and in the Pharmacology section, is it strictly necessary with all those ® signs? It's not like you'd write Microsoft® Windows® each time you refer to that family of OSes, e.g. DarkPhoenix 15:01, 8 January 2007 (UTC)
- Okay, why not replace that template with a section specific one. PhoenixTwo 17:13, 6 March 2007 (UTC)
[edit] Diseases vs Disorders
Perhaps the section named "Diseases" should be changed to "Disorders," since Metabolic syndrome is not a disease, though Cushing's is. (Also, the wording of the two descriptions, as it now stands, lacks consistency.) D021317c 09:10, 8 February 2007 (UTC)
