Common gamma chain

From Wikipedia, the free encyclopedia

interleukin 2 receptor, gamma (severe combined immunodeficiency)
Identifiers
Symbol	IL2RG SCIDX1, IMD4
HUGO	6010
Entrez	3561
OMIM	308380
RefSeq	NM_000206
UniProt	P31785
Other data
Locus	Chr. X q13

Common gamma chain (γ_c) is a cytokine receptor subunit that is located on the surface of certain sub-sets of lymphocytes (white blood cells). It has one end outside the cell like an antenna and the other end inside to transmit signals to the cell's nucleus. The common gamma chain partners with other ligand-specific receptors to direct lymphocytes to respond to cytokines including IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and direct programs of cellular differentiation.

[edit] External links

• MeSH Interleukin+Receptor+Common+gamma+Subunit