Combes quinoline synthesis
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The Combes quinoline synthesis is a chemical reaction involving the condensation of unsubstituted anilines (1) with β-diketones (2) to form substituted quinolines (4) after an acid-catalyzed ring closure of an intermediate Schiff base (3).
[edit] References
- ^ Combes, A. Bull. Chim. Soc. France 1888, 49, 89.
- ^ Bergstrom, F. W. Chem. Rev. 1944, 35, 156. (Review)
[edit] See also
- Conrad-Limpach reaction
- Doebner reaction
- Doebner-Miller reaction
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