Collins reagent

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The Collins reagent is the complex of chromium(VI) oxide with pyridine in dichloromethane. The complex is both difficult and dangerous to prepare, as it is very hygroscopic and not very soluble in dichloromethane. It is usually used in a six-fold excess in order to complete the reaction. It is used to selectively oxidize primary alcohols to their aldehydes and will tolerates many functional groups within the molecule. It can be used as an alternative to the Jones reagent when oxidising secondary alcohols to ketones.

  1. J. C. Collins, W.W. Hess, Organic Syntheses, Coll. Vol. 6, p.644
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