Cohesin

Cohesin
Cohesin. Cohesin, binds sister chromatids together during metaphase (PDB: 1w1w).
Genetic data
Gene code:	[1] ID#: GI:2570096
Protein Structure/Function
Structure:	[2]1W1W
Related information
Recent publications:	[3] Cohesins: chromosomal proteins that prevent premature separation of sister chromatids., [4] A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae., [5] Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication., [6]Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1.

Cohesin is the protein responsible for binding the sister chromatids during mitosis after S phase. At metaphase, most cohesin is removed, except for some at the centromere. At Anaphase, securin, an inhibitory subunit of separase, is hydrolyzed. Separase hydrolyzes the remaining cohesin.