Cloxacillin
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Cloxacillin
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| Systematic (IUPAC) name | |
| (2S,5R,6R)-6-{[3-(2-chlorophenyl)-5-methyl- oxazole-4-carbonyl]amino}-3,3-dimethyl-7-oxo- 4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid |
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| Identifiers | |
| CAS number | |
| ATC code | J01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C19H18ClN3O5S |
| Mol. mass | 435.882 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 37 to 90% |
| Protein binding | 95% |
| Metabolism | ? |
| Half life | 30 minutes to 1 hour |
| Excretion | Renal and biliary |
| Therapeutic considerations | |
| Pregnancy cat. |
B(US) |
| Legal status | |
| Routes | Oral, IM |
Cloxacillin is a semisynthetic antibiotic in the same class as penicillin. It is sold under a number of trade names, including Cloxapen® and Orbenin®. Cloxacillin is used against staphylococci that produce beta-lactamase.
This drug has a weaker antibacterial activity than benzylpencillin, and is devoid of serious toxicity except for allergic reactions.
[edit] See also
Amoxicillin, Ampicillin, Azlocillin, Carbenicillin, Cloxacillin, Dicloxacillin, Flucloxacillin, Mezlocillin, Nafcillin, Piperacillin, Pivampicillin, Ticarcillin
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